Suicidal ideation among people with Parkinson's disease and comparison with a control group

Santos‐García, Diego; Bartolomé, Carlos Cores; Panceiras, Maria J. Feal; Díaz, Iago García; Alvarado, María Cristina Íñiguez; Boungiorno, Maria Teresa; Cabo, Iria; Aramburu, Isabel González; Rivera, María A. Ávila; Padilla, Francisco Carrillo; Martínez, Javier Rúiz; Fábregues, Oriol de; Daniela, Adarmes Astrid; Almeria, Marta; Losada, Maria G. Alonso; Cánovas, Araceli; Frech, Fernando Alonso; Redondo, Ruben Alonso; Álvarez, Ignacio; Saúco, María Álvarez; Díaz, A Aneiros; Arnáiz, Sandra; Arribas, Sonia; Vidondo, Arancha Ascunce; Aguilar, Miquel; Ávila, Maria Asunción; Lambrich, Noemí Bernardo; Bejr‐Kasem, Helena; Estrada, Marta Blázquez; González, Maria Ángeles Botí; Borrué, Carmen; Buongiorno, Maria Teresa; González, Carolina Cabello; López, Iria Cabo; Caballol, Núria; Lorenzo, Ana Cámara; Medina, Héctor Canfield; Carrillo, Fátima; Padilla, Francisco José Carrillo; Peña, Elena Casas; Catalán, María José; Clavero, Pedro; Fernández, A. Cortina; Cosgaya, Marina; Foraster, Anna Cots; Cuevas, A. Crespo; Cubo, Esther; Fonticoba, Teresa de Deus; Fábregues‐Boixar, Oriol de; Díez-Fairén, Mónica; García‐Soto, Julio Dotor; Erro, Elena; Escalante, Sonia; Peyret, Elena Estelrich; Guillán, Noelia Fernández; Gámez, Pedro; Gallego, Mercedes; Caldentey, Juan García; Campos, Cristina García; Díez, Cristina García; Moreno, José Manuel García; Gastón, Itziar; Garre, María del Pilar Gómez; Mayordomo, Víctor Gómez; Aloy, J. González; González‐Aramburu, Isabel; Ardura, Jessica González; García, B. González; Palmás, Maria Josefa González; Toledo, Gabriel Ricardo González; Díaz, Ana Golpe; Solà, Mireia Grau; Guardia, Gemma; Vara, Jorge Hernández; Horta‐Barba, Andrea; Calderón, Daniel Idoate; Infante, Jon; Jesús, Silvia; Kulisevsky, Jaime; Kurtis, Mónica; Labandeira, Carmen M.; Espinosa, Miguel Ángel Labrador; Lacruz, Francisco Agramunt; Castro, M. Lage; Gómez, Sonia Lastres; Legarda, I; Ariztegui, Nuria López; Díaz, Luis M. López; Domínguez, Daniel López; Manzanares, Lydia López; Seoane, B. López; Pozo, Sara Lucas del; Macías, Yolanda; Mata, Marina; Martí-Andrés, Gloria; Martı́, Marı́a José; Castrillo, Juan Carlos Martínez; Martinez‐Martín, Pablo; McAfee, Darrian; Meitín, M.T.; Plasencia, Zebenzui Mendoza; González, Manuel Menéndez; Barrio, Carlota Méndez del; Mir, Pablo; Santiago, Javier Miranda; Morales-Casado, María Isabel; Diéguez, Antonio Moreno; Nogueira, Víctor; Amado, Alba Novo; Ponte, Sabela Novo; Ordás, Carlos; Pagonabarraga, Javier; Pareés, Isabel; Pascual‐Sedano, Berta; Pástor, Pau; Fuertes, A. Pérez; Noguera, Rafael Pérez; Planas‐Ballvé, Ana; Planellás, Lluís; Prats, Marian Ángeles; Jurczynska, C. Prieto; Puente, Víctor; Morlans, Mercedes Pueyo; Daví, Arnau Puig; Rafales, N. Redondo; Méndez, Luisa Rodríguez; Pérez, Amparo Belén Rodríguez; Roldán, Florinda; Arcos, María Ruíz de; Alonso, Pilar Sánchez; Sánchez‐Carpintero, Macarena; Díez, G. Sánchez; Rodríguez, A; Santacruz, Pilar; García, Diego Santos; Rodríguez, J. C. Segundo; Seijo, Manuel; Peña, María Sierra; Vila, Berta Solano; Castro, Ester Suárez; Tartari, Juan Pablo; Valero, Caridad; Vargas, Laura; Vela, Lydia; Villanueva, Clara; Vives, Bárbara

doi:10.1002/gps.5919

Cited by 2 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these, 15 studies were cross-sectional studies, 8 were retrospective cohort studies, and 3 were case-control studies. Santos-Garcia et al used a prospective cohort design, while Kostic et al used both cross-sectional and cohort study designs. Only 3 of the studies reported a follow-up period: Kostic et al reported that the patients were followed up with for 8 years, Lee et al reported a mean follow-up time of 7.1 (SD, 4.1) years, and Santos-Garcia et al reported that patients were followed up for 2 years.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Risk of Suicidal Ideation and Behavior in Individuals With Parkinson Disease

Mai,

Chao,

Xiao

et al. 2024

JAMA Neurol

View full text Add to dashboard Cite

ImportanceSuicide risk may be increased in patients with Parkinson disease (PD), a common neurodegenerative condition. Mood disorders, especially depression, are prevalent in patients with PD who report suicidality.ObjectiveTo address inconsistent results from studies of suicidal ideation and behavior in patients with PD.Data SourcesThe study team searched MEDLINE and Embase from inception to June 14, 2023, and further screened the bibliographies of relevant studies to ensure a comprehensive search.Study SelectionOriginal studies, published in English, discussing either suicidal ideation, behavior, or both in adults with PD were included. Accepted study designs included cross-sectional, case-control, and cohort studies. Studies that only included patients with PD after deep brain stimulation were excluded.Data Extraction and SynthesisThis meta-analysis was conducted in line with the PRISMA guidelines. Two authors reviewed each study and extracted the data independently, with discrepancies referred to a third independent author.Main Outcomes and MeasuresOutcomes included the prevalence of suicidal ideation and behavior, measured as proportions, and the risk of suicidal behavior in patients with PD relative to controls, measured in both odds ratio (OR) and hazards ratio (HR).ResultsA total of 28 studies comprising 505 950 PD patients were included in the final analysis. The prevalence of suicidal ideation was evaluated in 14 studies (22.2%; 95% CI, 14.6-32.3) and suicidal behavior in 21 studies (1.25%; 95% CI, 0.64-2.41). Excluding 4 outliers, prevalence of suicidal behavior was significantly higher in prospective studies (1.75%; 95% CI, 1.03-2.95) than retrospective studies (0.50%; 95% CI, 0.24-1.01). Excluding 1 outlier, OR of suicidal behavior was pooled across 10 studies and significant (OR, 2.15; 95% CI, 1.22-3.78; P = .01). HR of suicidal behavior was assessed in 9 studies (HR, 1.73; 95% CI, 1.40-2.14; P &lt; .001).Conclusions and RelevanceThis meta-analysis involving more than 500 000 patients with PD found 22.2% and 1.25% of patients with PD to have suicidal ideation and behavior, respectively. Patients with PD had 2 times the risk of suicidal behavior than controls. Early recognition and management of suicidality in PD can help reduce mortality.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Influence analysis revealed 3 outliers: Merschdorf et al, Santos-Garcia et al, and Dissanayaka et al A sensitivity analysis excluding them was conducted and found the prevalence to be 24.0% (95% CI, 19.1-29.7). The I 2 index was 89.0% and the Cochran Q test was significant at P < .001.…”

Section: Resultsmentioning

confidence: 99%