Suicidal Ideation in Patients Experiencing a First‐episode Psychosis: Findings From the 2‐Year Follow‐up of the “Parma Early Psychosis” Program

Pelizza, Lorenzo; Pellegrini, Clara; Quattrone, Emanuela; Azzali, Silvia; Landi, Giulia; Pellegrini, Pietro; Leuci, Emanuela

doi:10.1111/sltb.12625

Cited by 28 publications

(23 citation statements)

References 58 publications

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“…A meta-analysis [ 17 ] showed the pooled lifetime prevalence of SA was 26.8% (95% CI: 22.1−31.9%) among people living with schizophrenia. In contrast, no meta-analysis was published for pooled SI, and the estimates within individual studies [ 18 – 23 ] ranging between 11.0% in China [ 23 ] and 51.4% in the USA [ 21 ]. This is the similar case for SP among people living with schizophrenia [ 24 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

Worldwide prevalence of suicidal ideation and suicide plan among people with schizophrenia: a meta-analysis and systematic review of epidemiological surveys

et al. 2021

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Schizophrenia is a severe psychiatric disorder with high premature mortality rates. This is a meta-analysis and systematic review of the prevalence of suicidal ideation (SI) and suicide plan (SP) among people with schizophrenia. PubMed, Web of Science, Embase, and PsycINFO were systematically searched from their respective inception to October 10, 2020. Data on prevalence of SI and/or SP were synthesized using the random effects model. Twenty-six studies covering 5079 people with schizophrenia were included for meta-analysis. The lifetime and point prevalence of SI were 34.5% (95% CI: 28.2−40.9%), and 29.9% (95% CI: 24.2−35.6%), respectively. The lifetime prevalence of SP was 44.3% and the point prevalence of SP ranged between 6.4 and 13%. Subgroup and meta-regression analyses revealed that source of patients, survey countries, and sample size were significantly associated with the point prevalence of SI, while male proportion and quality assessment scores were significantly associated with the lifetime and point prevalence of SI. Survey time and mean age were significantly associated with lifetime prevalence of SI. Both SI and SP are common in people living with schizophrenia, especially in males and inpatients. Routine screening and effective interventions for SI and SP should be implemented in this population.

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Section: Introductionmentioning

confidence: 99%

Worldwide prevalence of suicidal ideation and suicide plan among people with schizophrenia: a meta-analysis and systematic review of epidemiological surveys

et al. 2021

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“…Current or past significant depressive symptoms are associated with suicide risk in patients after FEP [ 15 , 31 – 34 ]. The prevalence of depressive symptoms after FEP ranges from 14.15% to 44.80%.…”

Section: Introductionmentioning

confidence: 99%

Suicidal behaviour after first-episode psychosis: results from a 1-year longitudinal study in Portugal

et al. 2021

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Background Suicide is one of the main causes of excess of premature death in psychotic patients. Published studies found that suicide risk begins in ultra-high risk of psychosis and continues in early years of the disease. Previous studies identifying predictive and risk factors associated with suicidality in first-episode psychosis (FEP) are highly inconsistent. Also, there are relatively few longitudinal studies on suicidal behaviour in FEP. The aim of this study was to examine prevalence, evolution and predictors of suicidal behaviour at baseline and the 12-month follow-up in patients presenting with FEP. Methods One hundred and eighteen patients presenting with FEP were recruited from two early psychosis units in Portugal. A comprehensive assessment examining socio-demographic and clinical characteristics was administered at baseline and the 12-month follow-up. Odds ratio were calculated using logistic regression analyses. McNemar test was used to evaluate the evolution of suicidal behaviour and depression prevalence from baseline to 12 months of follow-up. Results Follow-up data were available for 60 participants from the 118 recruited. Approximately 25.4% of the patients had suicidal behaviour at the baseline evaluation, with a significant reduction during the follow-up period to 13.3% (p = 0.035). A multivariate binary logistic regression showed that a history of suicidal behaviour and depression at baseline independently predicted suicidal behaviour at baseline, and a history of suicidal behaviour and low levels of total cholesterol predicted suicidal behaviour at the 12-month follow-up. A significant proportion of patients also had depression at the baseline evaluation (43.3%), with the last month of suicidal behaviour at baseline independently predicting depression at this time. Conclusions The findings of our study indicate that suicidal behaviour was prevalent on the year after FEP. Patients with a history of suicidal behaviour, depression at baseline and low levels of cholesterol should undergo close evaluation, monitoring and possible intervention in order to reduce suicide risk in the early phases of psychosis.

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“…The assumption that specific biological abnormalities may be related or even predict a suicide attempt is of great importance given the availability of such data in everyday clinical practice. Physicians of any kind as well as mental health professionals should be aware of the importance to insert as much information possible in the assessment of suicide risk (Pelizza et al, 2020a).…”

Section: Introductionmentioning

confidence: 99%

Suicidal thinking and behaviours in First Episode Psychosis: Findings from a 3‐year longitudinal study

Pelizza

Pompili

Azzali

et al. 2020

Early Intervention Psych

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Aim: Suicide risk is greater at the beginning of the course of psychosis. Purpose of this research was: (a) to investigate prevalence and incidence rates of suicide attempts, suicidal thinking and completed suicide in First Episode Psychosis (FEP) help-seekers as compared with non-FEP help-seeking peers, and (b) to examine any correlation of suicidal ideation with other baseline psychopathological predictors. Methods: Two hundred and forty-one young people (13-35 years) were assessed with the World Health Organization Quality Of Life scale -Brief version (WHOQOL-BREF), the Beck Depression Inventory -II Edition (BDI-II) and the Comprehensive Assessment of At-Risk Mental States (CAARMS) at the enrollment and over a 36month follow-up period. A Kaplan-Meier survival analysis to calculate cumulative incidence rates of attempted and completed suicide was used.Results: FEP patients showed more severe levels of CAARMS "Suicidality/Self-Harm" item than non-FEP peers. They also had higher 3-year incidence rates of attempted suicide (11%) and completed suicide (13%). Within the FEP total group, suicidal ideation was positively correlated with BDI-II and CAARMS "Perceptual Abnormalities" item scores, and showed negative associations with younger age and WHOQOL-BREF "Social Relationships" factor sub-score.Conclusions: Suicidal ideation is relevant in FEP patents, supporting the routine monitoring of suicide risk in baseline assessment of adolescents and young adults with early psychosis. Suicidal thinking seems to be correlated to younger age, perceptual aberrations and depression severity, as well as to poorer quality of social relationships.

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Suicidal Ideation in Patients Experiencing a First‐episode Psychosis: Findings From the 2‐Year Follow‐up of the “Parma Early Psychosis” Program

Cited by 28 publications

References 58 publications

Worldwide prevalence of suicidal ideation and suicide plan among people with schizophrenia: a meta-analysis and systematic review of epidemiological surveys

Worldwide prevalence of suicidal ideation and suicide plan among people with schizophrenia: a meta-analysis and systematic review of epidemiological surveys

Suicidal behaviour after first-episode psychosis: results from a 1-year longitudinal study in Portugal

Suicidal thinking and behaviours in First Episode Psychosis: Findings from a 3‐year longitudinal study

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