Suicidal poisonings with methadone in France: Results of a two year national survey by the Toxicovigilance Network

Glaizal, Mathieu; Gazin, Vincent; Aymard, Isabelle; Messina-Gourlot, Catherine; Richard, Nathalie; Mallaret, Michel; Saviuc, Philippe; Haro, Luc de

doi:10.3109/15563650.2012.731510

Cited by 10 publications

(7 citation statements)

References 7 publications

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“…The study on galenic methadone formulations confirmed previously published results [1,2]. Formulation was provided in 1127 files (80% of the series), with 629 (55.8%) cases involving methadone capsules and 498 (36%) cases involving methadone syrup.…”

Section: Comparison Between Methadone Capsules Vs Methadone Syrupsupporting

confidence: 83%

“…This series of methadone exposures on a national scale is one of the largest compiled series in international medical literature. It enabled the clarification or confirmation of several notions which had already been highlighted in two previous papers involving the experience of poison centres in France on methadone exposure [1,2]. First of all, it confirms that methadone is not a harmless drug: this molecule is responsible for serious and sometimes fatal accidents happening to children [2] and is just as dangerous for adults.…”

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 66%

“…Results of these first surveys showed that, in children and adults, both intentional as unintentional methadone exposure involving one or other of these formulations were responsible for serious and life-threatening poisonings. However, no difference in severity regarding the exposed methadone formulation was observed [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Methadone poisonings: a seven‐year retrospective study of the French poison center network focusing on suicide attempts vs. misuses

Torrents¹,

Glaizal²,

Sinno‐Tellier

et al. 2019

Fundamemntal Clinical Pharma

Self Cite

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Methadone has been prescribed in France as opioid substitution therapy as a syrup formulation since 1995 and as capsules since 2008. Following two publications showing on a national scale the high risk of methadone poisoning in children and the lack of difference in poisoning severity between both methadone formulations, French health authorities chose to benefit from the experience acquired by the network of French poison centres concerning poisoning by this substitution medication. The aim of this study was to identify and compare the main circumstances of methadone exposure collected by a poison centre on a national scale over a period of 7 years. Retrospective descriptive study of cases of methadone exposure was compiled by the network of French poison centres between 15 October 2010 and 15 October 2017. Analysis of 1415 files revealed two major circumstances: 47% misuse and 41% suicide attempts. Severity scores evaluated according to the PSS were higher for misuse than for suicidal behaviour, despite the supposed ingested dose being statistically higher in the latter. The results also confirmed the lack of significant difference in methadone exposure between both of the formulations (syrup and capsules). This series of methadone exposure on a national scale is one of the largest compiled series in international medical literature. On the one hand, it highlights the severity of methadone poisoning (in suicidal behaviour and even more so in misuse behaviour), and on the other hand, it confirms that the capsule formulation does not seem to represent a higher risk than the syrup formulation.

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Section: Comparison Between Methadone Capsules Vs Methadone Syrupsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Methadone poisonings: a seven‐year retrospective study of the French poison center network focusing on suicide attempts vs. misuses

Torrents¹,

Glaizal²,

Sinno‐Tellier

et al. 2019

Fundamemntal Clinical Pharma

Self Cite

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“…Concerning drug-related deaths, for example in France, data collected in the framework of DRAMES (relationship with death and drugs or substance abuse [décès en relation avec l'abus de médicaments et de substances]) do not cover all drug-related deaths in the country. [41] By contrast, in Scandinavian countries such as Finland or Norway, toxicological analyses are recorded in a national exhaustive registry. [42,43] Launiainen et al found that pregabalin was identified as frequently as oxycodone in deaths occurring in young population (15-34 years), with two thirds of these deaths related with abuse.…”

Section: Toxicology Databasesmentioning

confidence: 99%

Drug Abuse Monitoring: Which Pharmacoepidemiological Resources at the European Level?

Lapeyre‐Mestre

Dupui

2015

Therapies

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-Monitoring the potential for abuse and dependence of psychoactive substances falls within the scope of international conventions on narcotic drugs. At the European level, this monitoring is based on activities controlled by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) for substance abuse in general and by the European Medicines Agency (EMA) for marketed drugs, in the context of pharmacovigilance. If France has set up in the early 1990s an original system to assess potential for abuse of psychoactive substances, with specific tools combining both the evaluation of the use of these substances (illicit substances or diverted drugs), and the consequences of that use in terms of morbidity and mortality, there is no equivalent in other European countries. Indeed, unlike the USA, who, for several decades, organized this type of surveillance, with a multisource approach (sentinel systems, databases, medical and administrative data, databases for seeking care in relation abuse), we have not found in other European countries integrated system for identifying a signal of drug abuse, or to assess the impact of measures for minimizing the risk of abuse. However, some recent examples show a growing concern about drug addiction, based on a pharmacoepidemiological approach using pharmacovigilance databases or medical administrative data. These examples illustrate the interest of these approaches in the field of drug of abuse.Abbreviations: see end of article.

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Réponse à l’urgence et toxicovigilance : bilan de 11ans de consultations du centre antipoison de Marseille (2002–2012)

Glaizal

Schmitt

Tichadou

et al. 2014

Toxicologie Analytique et Clinique

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Suicidal poisonings with methadone in France: Results of a two year national survey by the Toxicovigilance Network

Abstract: In France, suicide attempts were more likely to occur with the capsule formulation. The clinical severity of intoxication was similar between the capsule and liquid forms.

Cited by 10 publications

References 7 publications

Methadone poisonings: a seven‐year retrospective study of the French poison center network focusing on suicide attempts vs. misuses

Methadone poisonings: a seven‐year retrospective study of the French poison center network focusing on suicide attempts vs. misuses

Drug Abuse Monitoring: Which Pharmacoepidemiological Resources at the European Level?

Réponse à l’urgence et toxicovigilance : bilan de 11ans de consultations du centre antipoison de Marseille (2002–2012)

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