Suicidal Thoughts Are Associated with Platelet Counts in Adolescent Inpatients

Ragolsky, Micha; Shimon, Hady; Shalev, Hadar; Weizman, Abraham; Rubin, Eitan

doi:10.1089/cap.2012.0057

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…However, serotonin is carried by blood platelets and has been shown to exhibit seasonal fluctuation (21,22). A recent study even finds a direct relationship between platelet count and suicidal thoughts (32). In addition, a common variant in the neurogranin (NRGN) gene is associated with schizophrenia (33) and was identified as an intracellular platelet expressed gene highlighted by Gnatenko and colleagues (29).…”

Section: Discussionmentioning

confidence: 99%

Seasonal changes in gene expression represent cell-type composition in whole blood

Jong

Neeleman

Luykx

et al. 2014

Human Molecular Genetics

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Seasonal patterns in behavior and biological parameters are widespread. Here, we examined seasonal changes in whole blood gene expression profiles of 233 healthy subjects. Using weighted gene co-expression network analysis, we identified three co-expression modules showing circannual patterns. Enrichment analysis suggested that this signal stems primarily from red blood cells and blood platelets. Indeed, a large clinical database with 51 142 observations of blood cell counts over 3 years confirmed a corresponding seasonal pattern of counts of red blood cells, reticulocytes and platelets. We found no direct evidence that these changes are linked to genes known to be key players in regulating immune function or circadian rhythm. It is likely, however, that these seasonal changes in cell counts and gene expression profiles in whole blood represent biological and clinical relevant phenomena. Moreover, our findings highlight possible confounding factors relevant to the study of gene expression profiles in subjects collected at geographical locations with disparaging seasonality patterns.

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Section: Discussionmentioning

confidence: 99%

Seasonal changes in gene expression represent cell-type composition in whole blood

Jong

Neeleman

Luykx

et al. 2014

Human Molecular Genetics

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“… 10 , 19 , 20 Patients with some psychiatric disorders have raised platelet counts. 18 , 21 Varsak et al 22 found that the NLR was significantly higher in first episode psychosis (FEP) versus control groups.…”

Section: Introductionmentioning

confidence: 99%

Is Vitamin B12 Level a Reliable Predictor of Psychosis Severity in Male Patients with Megaloblastic Anemia at a Single Tertiary Hospital?

Wafaa¹,

Magadmi²,

Hakami³

et al. 2022

IJGM

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Background Megaloblastic anemia (MA) occurs due to ineffective erythropoiesis, which results from impaired DNA synthesis in the hematopoietic precursors and intramedullary hemolysis. MA’s most common cause is nutritional deficiencies of either cobalamin (vitamin B12) or folate (vitamin B6). This study aims to determine the association between MA caused by vitamin B12 deficiency and psychosis among psychotic male patients in Mental Health Hospital at Taif, Saudi Arabia. Methods Fifty psychotic male patients, aged 48.58±1.72, were recruited from the Mental Health Hospital at Taif, Saudi Arabia, in addition to 54 sex-matched healthy controls. The following tests were run: complete blood count (CBC), liver function tests (LFT), serum levels of vitamin B12, folate, and C-reactive protein (CRP). Results The CBC showed that RBCs count, haemoglobin, haematocrit, platelets count, mean platelets volume (MPV), and absolute lymphocyte count were significantly lower in psychotic patients versus healthy controls (P=0.007, P=0.002, P=0.001, P=0.004, P=0.0001, and P=0.005, respectively). In contrast, the eosinophil absolute count and basophil percentage were significantly higher in psychotic patients versus controls (P=0.009, P=0.0001, respectively). Vitamin B12 levels were insignificantly decreased in psychotic patients versus healthy group. There were significant negative correlations between serum levels of VitB12 and negative symptoms (r=−0.381, P=0.006) and hallucination (r=−0.297, P=0.036). Conclusion These findings indicate no link between MA induced by VitB12 insufficiency and psychosis among psychotic patients. However, low serum VitB12 can predict the severity of some psychosis signs, including hallucinations and negative symptoms. Therefore, monitoring VitB12 levels and its supplementation in psychotic patients is recommended to improve their symptoms.

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“…al. 2017; Ataoğlu and Canan 2009), and higher in hospitalized adolescents with suicidality than in non-suicidal inpatients and controls(Ragolsky et al 2013). Regarding coagulation potential, larger platelets have more granules and receptors and a greater tendency to clot than small platelets.…”

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confidence: 96%

High PLC-C level in major depressive disorder and its relationship with disease severity: a different perspective on coagulation in major depressive disorder

Yılmaz¹,

Öner²

2022

nin

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Introduction: Large platelets are an important risk factor for the development of thrombosis. In this study, we aimed to measure the presence of large cell platelets and its relationship with disease severity in major depressive disorder (MDD). Material and methods: In this study, platelet volume indices were analyzed from the complete blood count (CBC) results of 103 cases (51 MDD and 52 controls) analyzed retrospectively. For the experimental group of MDD patients, the Hamilton Depression Rating Scale (HAM-D) and Hamilton Anxiety Rating Scale (HAM-A) were applied and compared to platelet parameters. Results:The study found that platelet large cell ratio (PLC-R) and platelet large cell count (PLC-C) values were higher in the MDD group compared to healthy controls. ROC analysis showed that PLC-C > 91.24 had 70.6% sensitivity and 80.8% specificity for MDD. Pearson correlation analysis showed that PLC-C values and HAM-D scores correlated positively in MDD patients. Conclusions: A simple CBC analysis detects PLC-R and PLC-C. Indices that give the ratio (PLC-R) and number (PLC-C) of larger and more active platelets in terms of coagulation should be emphasized. Our study found higher PLC-R and PLC-C values in patients with MDD compared to the control group, and increased PLC-C values with increased severity of depression. Thus PLC-C may be a useful marker for the increased coagulation activity observed in MDD patients and MDD patients with high PLC-R and PLC-C values may benefit from preventive antithrombotic therapy.

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Suicidal Thoughts Are Associated with Platelet Counts in Adolescent Inpatients

Abstract: PLT counts are higher in suicidal hospitalized adolescents than in nonsuicidal inpatients, as well as than in controls.

Cited by 10 publications

References 29 publications

Seasonal changes in gene expression represent cell-type composition in whole blood

Seasonal changes in gene expression represent cell-type composition in whole blood

Is Vitamin B12 Level a Reliable Predictor of Psychosis Severity in Male Patients with Megaloblastic Anemia at a Single Tertiary Hospital?

High PLC-C level in major depressive disorder and its relationship with disease severity: a different perspective on coagulation in major depressive disorder

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