Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump

Hrubisko, M; Gown, Allen; Prendiville, Joseph A; Radford, John; Thatcher, Nick; Fox, Brian W

doi:10.1007/bf00686261

Cited by 7 publications

(1 citation statement)

References 4 publications

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“…However, increased concentrations of cisplatin in the solutions were observed, which grew along with higher temperature (25°C < 1%, 37°C < 3%, 60°C – 8.2%). The phenomenon was most likely to have been caused by evaporation of the solvent [11]. On the other hand, Mitter et al .…”

Section: Resultsmentioning

confidence: 99%

The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%

Karbownik¹,

Szałek²,

Urjasz³

et al. 2012

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Aim of the studyThe subject of study was the stability of cisplatin in concentrate in glass vials and diluted in polyethylene (PE) bags stored at 15–25°C for up to 30 days.Material and methodsOriginal vials of cisplatin injection (1 mg/ml, Teva) were stored at room temperature and subjected to re-piercing after 1, 2, 3, 7, 14, 21, 28 and 30 days following the initial piercing. Cisplatin infusions at nominal concentrations of 0.1 mg/ml were prepared in 0.9% sodium chloride (1000 ml) in PE bags. Chemical stability was measured by means of a stability-indicating high-performance liquid chromatography (HPLC) assay. Physical stability was assessed by visual inspection in normal light.ResultsThe concentration of cisplatin at each sampling time in the analysed solutions remained within 92.0–100.7% of initial concentration, regardless of the container. No changes in colour or turbidity were observed in any of the vials or prepared solutions.ConclusionsCisplatin, both undiluted in glass containers and diluted with NaCl 0.9% in PE bags, remains stable (< 10% degradation) for at least 30 days at room temperature when protected from light.

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Section: Resultsmentioning

confidence: 99%