Sulcal Pattern Variability and Dorsal Anterior Cingulate Cortex Functional Connectivity Across Adult Age

Fedeli, Davide; Maschio, Nicola Del; Caprioglio, Camilla; Sulpizio, Simone; Abutalebi, Jubin

doi:10.1089/brain.2020.0751

Cited by 15 publications

(19 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also saw individual variability in the size of another brainstem nucleus, the PMD (Baizer et al 2007). Individual variability in cortical sulcal and gyral patterns is well-established, and has clear functional correlates (Régis et al 2005;Fedeli et al 2020;Bonte et al 2013;Glasel et al 2011). Our data clearly show that there is variability in brainstem structures in humans as well, but the functional correlates are so far unknown.…”

Section: Variability and Asymmetry Of The Arc And Ioprsupporting

confidence: 51%

Individual variability in the size and organization of the human arcuate nucleus of the medulla

Baizer

Witelson

2021

Preprint

View full text Add to dashboard Cite

The arcuate nucleus (Arc) of the medulla is found in almost all human brains and in a small percentage of chimpanzee brains. It is absent in the brains of other mammalian species including mice, rats, cats and macaque monkeys. The Arc is classically considered a precerebellar nucleus, presumably motor in function. However, several studies have found aplasia of the Arc in babies who died of SIDS (Sudden Infant Death Syndrome) suggesting a very different role for the Arc in the control of respiration. Aplasia of the Arc, however, has also been reported in adults suggesting that it is not critical for survival. We have examined the Arc in closely-spaced Nissl-stained sections in human cases to acquire a better understanding of the degree of variability of its size and location in adults. We have also examined immunostained sections to develop a neurochemical profile of this nucleus. Our data suggest that the Arc consists of rostral and caudal subdivisions. There is some degree of left-right asymmetry in Arc position, size and shape at all rostro-caudal levels. Neurons in the Arc express calretinin (CR), neuronal nitric oxide synthase (nNOS) and nonphosphorylated neurofilament protein (NPNFP) but not calbindin (CB) or parvalbumin (PV). There is also immunostaining for GAD and GABA receptors suggesting inhibitory input to Arc neurons. We support the classical idea of the Arc as a precerebellar nucleus; its absence in SIDS cases may not be the cause of death but rather a correlate of other brainstem abnormalities.

show abstract

Section: Variability and Asymmetry Of The Arc And Ioprsupporting

confidence: 51%

Individual variability in the size and organization of the human arcuate nucleus of the medulla

Baizer

Witelson

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Should this association be proven significant, it would be the first account of a direct link between prenatally determined aMCC variability, functional activity, and differences in behavioral performance. Individual differences in aMCC sulcal pattern have been previously reported to modulate brain connectivity at rest 31 , as well as the spatial distribution of local task-related clusters of functional activity during decision-making 32 , saccadic and tongue movements 33 , word generation 34 , and pain processing 35 . While these findings are not specific for tasks involving EFs, they represent a promising argument to hypothesize an association between aMCC sulcal pattern and modulation of brain activity during response inhibition.…”

mentioning

confidence: 99%

Cingulate cortex morphology impacts on neurofunctional activity and behavioral performance in interference tasks

Fedeli

Maschio

Mauro

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Inhibitory control is the capacity to withhold or suppress a thought or action intentionally. The anterior Midcingulate Cortex (aMCC) participates in response inhibition, a proxy measure of inhibitory control. Recent research suggests that response inhibition is modulated by individual variability in the aMCC sulcal morphology. However, no study has investigated if this phenomenon is associated with neurofunctional differences during a task. In this study, 42 participants performed an Attention Network Task and a Numerical Stroop task in an MRI scanner. We investigated differences in brain activity and response inhibition efficiency between individuals with symmetric and asymmetric aMCC sulcal patterns. The results showed that aMCC morphological variability is partly associated with inhibitory control, and revealed greater activation in individuals with symmetric patterns during the Stroop task. Our findings provide novel insights into the functional correlates of the relationship between aMCC morphology and executive abilities.

show abstract

“…In this respect, the brainstem echoes the cerebral cortex. Individual differences both in sulcal and gyral patterns, as well as the extent of different cytoarchitectonic areas are well-established for the human cerebral cortex ( Seidenwurm et al, 1985 ; Paus et al, 1996 ; Bartley et al, 1997 ; review in Ochiai et al, 2004 ; Uylings et al, 2005 ; Caspers et al, 2006 ; Fornito et al, 2006 ; Cykowski et al, 2008 ; Scheperjans et al, 2008 ; Zlatkina and Petrides, 2010 ; Fedeli et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of four nuclei in the human brainstem: Individual differences, left-right asymmetry, species differences

Baizer

Witelson²

2023

Front. Neuroanat.

View full text Add to dashboard Cite

IntroductionIt is commonly thought that while the organization of the cerebral cortex changes dramatically over evolution, the organization of the brainstem is conserved across species. It is further assumed that, as in other species, brainstem organization is similar from one human to the next. We will review our data on four human brainstem nuclei that suggest that both ideas may need modification.MethodsWe have studied the neuroanatomical and neurochemical organization of the nucleus paramedianus dorsalis (PMD), the principal nucleus of the inferior olive (IOpr), the arcuate nucleus of the medulla (Arc) and the dorsal cochlear nucleus (DC). We compared these human brainstem nuclei to nuclei in other mammals including chimpanzees, monkeys, cats and rodents. We studied human cases from the Witelson Normal Brain collection using Nissl and immunostained sections, and examined archival Nissl and immunostained sections from other species.ResultsWe found significant individual variability in the size and shape of brainstem structures among humans. There is left-right asymmetry in the size and appearance of nuclei, dramatically so in the IOpr and Arc. In humans there are nuclei, e.g., the PMD and the Arc, not seen in several other species. In addition, there are brainstem structures that are conserved across species but show major expansion in humans, e.g., the IOpr. Finally, there are nuclei, e.g. the DC, that show major differences in structure among species.DiscussionOverall, the results suggest several principles of human brainstem organization that distinguish humans from other species. Studying the functional correlates of, and the genetic contributions to, these brainstem characteristics are important future research directions.

show abstract

Sulcal Pattern Variability and Dorsal Anterior Cingulate Cortex Functional Connectivity Across Adult Age

Cited by 15 publications

References 62 publications

Individual variability in the size and organization of the human arcuate nucleus of the medulla

Individual variability in the size and organization of the human arcuate nucleus of the medulla

Cingulate cortex morphology impacts on neurofunctional activity and behavioral performance in interference tasks

Comparative analysis of four nuclei in the human brainstem: Individual differences, left-right asymmetry, species differences

Contact Info

Product

Resources

About