Sulfamic Acid‐Catalyzed Multicomponent One‐Pot Synthesis of Poly‐Substituted Pyridines and Their Antimicrobial Activity

Banothu, Janardhan; Vijayalaxmi, S.; Rajitha, B.

doi:10.1002/jhet.1564

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…They are constituents of many pharmaceuticals and natural products, which reveal wide range of biological activity . Within a long‐term research program aimed at developing pharmaceutically active materials, synthesis of substituted pyridines are of special implication because of varied biological activities such as anticancer , antimicrobial , antibacterial , antifungal , anti‐inflammatory , antioxidant activity , cytotoxicity , and anti‐HIV . Thus, the synthesis of polysubstituted pyridine derivatives have fascinated many researchers, and several approaches have been pursued using catalysts, such as K 2 CO 3 , NaH , Et 3 N , [bmIm]OH , ZnCl 2 , DBU , MgO , KF/Al 2 O 3 , H 3 BO 3 , and NaOH .…”

Section: Introductionmentioning

confidence: 99%

Reusable Ce‐V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media

Maddila

Jonnalagadda

Lavanya³

2015

Journal of Heterocyclic Chem

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Ce‐V/Al2O3 as an effective heterogeneous catalyst is synthesized by a simple technique. The catalyst was identified by powder X‐ray diffraction, SEM, TEM, and BET surface area analysis. The catalyst is fully recyclable and reusable for several runs preserving its high activity. The catalytic activity of Ce‐V/Al2O3 is described by synthesis of a series of multisubstituted pyridines in good to excellent yields via a facile one‐pot multicomponent reaction within shorter reaction time.

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Section: Introductionmentioning

confidence: 99%

Reusable Ce‐V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media

Maddila

Jonnalagadda

Lavanya³

2015

Journal of Heterocyclic Chem

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“…In view of the high degree of bio-activity shown by pyrans, coumarins and pyrimidines, we have focused on the design of a novel structural entity that incorporates these three structural moieties into a single molecular scaffold to evaluate the potential additive effect on antimicrobial activity. Also, in continuation of our earlier studies on pyrimidinones, 32 we now elicit the synthesis of fused pyrano pyrimidinones utilizing inexpensive, eco-friendly and reusable Brønsted acidic ionic liquid as a catalyst under solvent-free conditions as marked antimicrobial agents.…”

Section: Introductionmentioning

confidence: 93%

Brønsted acidic ionic liquid catalysis: An efficient and eco-friendly synthesis of novel fused pyrano pyrimidinones and their antimicrobial activity

et al. 2013

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A series of novel fused pyrano pyrimidinones were synthesized by the condensation of 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles with 2-oxo-2H-chromene-3-carboxylic acid under neat conditions employing an efficient, eco-friendly and reusable Brønsted acidic ionic liquid, (4-sulfobutyl)tris(4sulfophenyl)phosphonium hydrogen sulphate as catalyst. All the synthesized compounds were characterized by their analytical and spectroscopic data and they were screened for in vitro antibacterial activity against Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis as Gram-positive, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia as Gram-negative bacterial strains and antifungal activity against Aspergillus flavus, Saccharomyces cerevisiae, Candida rugosa and Candida albicans. Compounds 2c and 2d have shown good antibacterial activity against Escherichia coli while 2g has shown marked antifungal activity against Candida rugosa.

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“…Furthermore, pyridine is an important class of heterocyclic ring, which have attracted attention in past few years. The pyridine nucleus exists in numerous natural products and is extremely important in the chemistry of biological systems, such as antioxidant activity [ 27 ], antimicrobial activity [ 28 ], acetylcholinesterase inhibitors [ 29 ], antibacterial activity [ 30 , 31 ], anticancer activity [ 32 , 33 ], anti-HBV activity [ 34 ], and so on. In the fungicidal activity area, some pyridine derivatives can prevent Ralstonia solanacearum [ 35 ], Cerospora beticola sacc.…”

Section: Introductionmentioning

confidence: 99%

Microwave Assistant Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing Pyridine Moiety

Sun

Yang

Shi

et al. 2014

IJMS

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In order to investigate the biological activity of novel 1,2,4-triazole compounds, seventeen novel 1,2,4-triazole derivatives containing pyridine moiety were synthesized under microwave assistant condition by multi-step reactions. The structures were characterized by 1H NMR, MS and elemental analyses. The target compounds were evaluated for their fungicidal activities against Stemphylium lycopersici (Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea in vivo, and the results indicated that some of the title compounds displayed excellent fungicidal activities. Theoretical calculation of the title compound was carried out with B3LYP/6-31G (d,p). The full geometry optimization was carried out using 6-31G (d,p) basis set, and the frontier orbital energy, atomic net charges were discussed, and the structure-activity relationship was also studied.

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Sulfamic Acid‐Catalyzed Multicomponent One‐Pot Synthesis of Poly‐Substituted Pyridines and Their Antimicrobial Activity

Cited by 6 publications

References 30 publications

Reusable Ce‐V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media

Reusable Ce‐V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media

Brønsted acidic ionic liquid catalysis: An efficient and eco-friendly synthesis of novel fused pyrano pyrimidinones and their antimicrobial activity

Microwave Assistant Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing Pyridine Moiety

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