2024
DOI: 10.1021/acsnano.4c00137
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Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

Xiaoyu Chen,
Ning Huang,
Danyang Wang
et al.

Abstract: Periodontitis, a prevalent chronic inflammatory disease worldwide, is triggered by periodontopathogenic bacteria, resulting in the progressive destruction of periodontal tissue, particularly the alveolar bone. To effectively address periodontitis, this study proposed a nanoformulation known as CuS@MSN-SCS. This formulation involves coating citrate-grafted copper sulfide (CuS) nanoparticles with mesoporous silica (MSNs), followed by surface modification using amino groups and sulfated chitosan (SCS) through ele… Show more

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Cited by 5 publications
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“…A scaffold, which has antibacterial properties, is beneficial for periodontal repair . Periodontal defects are formed due to the inflammation and immune mechanisms triggered by the interaction between periodontal pathogenic bacteria, including Porphyromonas gingivalis (P.…”
Section: Introductionmentioning
confidence: 99%
“…A scaffold, which has antibacterial properties, is beneficial for periodontal repair . Periodontal defects are formed due to the inflammation and immune mechanisms triggered by the interaction between periodontal pathogenic bacteria, including Porphyromonas gingivalis (P.…”
Section: Introductionmentioning
confidence: 99%