Sulfated Polysaccharides as Specific Biologically Active Materials

Muschin, Tegshi; Han, Shuqin; Ishimura, Hisataka; Yoshida, Takashi

doi:10.4052/tigg.23.292

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We assumed that the biological activity of sulfated polysaccharides was due to the electrostatic interaction between negatively charged sulfate groups and positively charged envelope proteins of the viruses. The interaction between sulfated polysaccharides and poly-l-lysine as a model compound of proteins was quantitatively investigated by surface plasmon resonance (SPR) measurements, suggesting that sulfated polysaccharides had fast association and slow dissociation rates on the immobilized poly-l-lysine [10]. These results indicate a high stability of the interaction.…”

Section: Introductionmentioning

confidence: 99%

Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers

Bai

Budragchaa

Han

et al. 2015

International Journal of Polymer Science

Self Cite

View full text Add to dashboard Cite

Sulfated glucopyranans having long alkyl groups were prepared by the ring-opening copolymerization of benzylated 1,6-anhydroglucopyranose with 3-O-octadecyl 1,6-anhydro-β-d-glucopyranose monomers, and subsequent deprotection and sulfation. Water-soluble sulfated glucopyranans with 2.8 and 4.7 mol% of 3-O-octadecyl group and lower molecular weights ofM-n= 2.5 × 103–5.1 × 103have potent anti-HIV activity at 0.05–1.25 μg/mL, even though sulfated polysaccharides with molecular weights belowM-n= 6 × 103had low anti-HIV activity. The interaction with poly-l-lysine as a model compound of proteins was analyzed by SPR, DSL, and zeta potential, indicating that the sulfated 3-O-octadecyl glucopyranans had high association and low dissociation rate constants, and the particle size increased after addition of poly-l-lysine. The anti-HIV activity was induced by electrostatic interaction between sulfate groups and amino groups of poly-l-lysine and by the synergistic effect of the hydrophobic long alkyl chain and hydrophilic sulfated group.

show abstract

Section: Introductionmentioning

confidence: 99%