Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline

Abstract

Introduction: Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods: In this cross-sectional study, we examined how cognitive decline and hippocampal subfields volume are associated with the expression of redox and inflammatory genes in peripheral blood. We analyzed 34 individuals with different cognitive scores according to Mini-Mental State Examination, corrected by age and education (adjMMSE). We identified a group presenting cognitive decline (CD) with adjMMSE<27 (n=14) and a normal cognition (NC) group with adjMMSE≥27 (n=20). A multiparametric approach, comprising structural magnetic resonance imaging measurement of different hippocampal segments and blood mRNA expression of redox and inflammatory genes was applied. Results: Our findings indicate that hippocampal segment volumes correlate positively with adjMMSE and negatively with the blood transcript levels of 19 genes, mostly redox genes correlating especially with the left subiculum and presubiculum. A strong negative correlation between hippocampal subfields atrophy and Sulfiredoxin-1 (SRXN1) redox gene was emphasized. Conclusions: Concluding, these results suggest that SRXN1 might be a valuable candidate blood biomarker for non-invasively monitoring the evolution of hippocampal atrophy in CD patients.

Identification of Key Genes and Biological Pathways in Bipolar Disorder by Bioinformatics and Next Generation Sequencing Data Analysis

“…Studies have also reported that CHRFAM7A [58], ACHE (acetylcholinesterase (Cartwright blood group) [305], HP (haptoglobin) [306], SELENBP1 [63], BASP1 [72], CHRNA1 [307], RPTN (repetin) [76], IL33 [308], TACR1[309], SHANK3 [310], ALOX12B [311], HPN (hepsin) [312], GFAP (glial fibrillary acidic protein) [84], CACNB2 [313], MYT1 [314], NOTCH3 [315], TERT (telomerase reverse transcriptase) [316], GNB3 [317], EGR3 [318], BSN (bassoon presynaptic cytomatrix protein) [319], CUX2 [320], GDF15 [321], CXCL8 [322], MAGI1 [95] and PAH (phenylalanine hydroxylase) [323] are necessary for BD development. S100A12 [324], CDH1 [325], S100A9 [326], ANK1 [327], KCNH2 [328], HP (haptoglobin) [329], FRMD4A [330], SNCA (synuclein alpha) [331], FBXO7 [332], PINK1 [333], B2M [334], KCNH3 [335], CA2 [336], FUZ (fuzzy planar cell polarity protein) [337], UBB (ubiquitin B) [338], C5AR1 [339], CBS (cystathionine beta-synthase) [340], F12 [341], TSPAN5 [342], NQO2 [343], NDUFA1 [344], SRXN1 [345], BASP1 [346], GPX1 [347], OLIG2 [348], EFHC2 [349], FOXA1 [350], PAX4 [351], BGN (biglycan) [352], IL33 [353], LRIG3 [354], GJA1 [355], SHANK3 [356], ARC (activity regulated cytoskeleton associated protein) [357], GFAP (glial fibrillary acidic protein) [358], UNC13A [359], MSTN (myostatin) [360], HSPG2 [361], TERT (telomerase reverse transcriptase) [362], GNB3 [363], L1CAM [364], CALB1 [365], RYR2 [366], MYO15A [367], MYH11 [368], GDF15 […”