Sulfonamides complexed with metals as mycobacterial biofilms inhibitors

Bonez, Pauline Cordenonsi; Agertt, Vanessa Albertina; Rossi, Grazielle Guidolin; Siqueira, Fallon dos Santos; Siqueira, Josiéli Demetrio; Marques, Lenice L.; Oliveira, Gelson Noe Manzoni de; Santos, Roberto Christ Vianna; Campos, Marli Matiko Anraku de

doi:10.1016/j.jctube.2021.100217

Cited by 13 publications

(7 citation statements)

References 31 publications

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“…Treatment of M. fortuitum is challenging because it has been reported to have high resistance to several drugs, including macrolides, aminoglycosides, and many antituberculosis drugs 18. However, M. fortuitum is almost always susceptible to sulfonamides, which in this case was successful in treating this patient’s infection 19…”

Section: Discussionmentioning

confidence: 80%

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Septic arthritis in a nonprosthetic joint due to Mycobacterium fortuitum: a case report

Rodriguez-Materon

Trynz

Giovanni

2022

Current Orthopaedic Practice

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Section: Discussionmentioning

confidence: 80%

“…18 However, M. fortuitum is almost always susceptible to sulfonamides, which in this case was successful in treating this patient's infection. 19…”

Section: Discussionmentioning

confidence: 99%

Septic arthritis in a nonprosthetic joint due to Mycobacterium fortuitum: a case report

Rodriguez-Materon

Trynz

Giovanni

2022

Current Orthopaedic Practice

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“…Coordination of the metal ion by the N atom from the heterocycle and the O atom of the -SO 2 NH-group, occurring in the case of Ru(III)-STZ and Ru(III)-SMZ, is one of the known modes of complexations in such systems [33]. Sulfonamides however can coordinate with metal ions in different ways [30,[33][34][35][36][37]. There could be found in the literature complexes with metal ions (e.g., Cu (II)) in which the coordination of the ion occurs only through the N atom of the thiadiazole ring [34], so the sulfonamide ligand, acts as a monodentate because neither the oxygen atom nor the nitrogen from the -SO 2 NHgroup are involved in coordination.…”

Section: Resultsmentioning

confidence: 99%

Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

Spisz

Chylewska

Królicka

et al. 2021

IJMS

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Antibiotic resistance is a global problem, and one promising solution to overcome this issue is using metallodrugs, which are drugs containing metal ions and ligands. These complexes are superior to free ligands in various characteristics including anticancer properties and mechanism of action. The pharmacological potential of metallodrugs can be modulated by the appropriate selection of ligands and metal ions. A good example of proper coordination is the combination of sulfonamides (sulfamerazine, sulfathiazole) with a ruthenium(III) ion. This work aimed to confirm that the activity of sulfonamides antibacterial drugs is initiated and/or stimulated by their coordination to an Ru(III) ion. The study determined the structure, electrochemical profile, CT-DNA affinity, and antimicrobial as well as anticancer properties of the synthesized complexes. The results proved that Ru(III) complexes exhibited better biological properties than the free ligands.

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“…Interestingly, AB-2-29 is not the first example of a metal complex displaying antibiofilm activity against M. abscessus . Indeed, metal complexes made of gold, silver, copper or cadmium-containing sulfonamides have recently been shown to display similar properties against a variety of NTM [ 46 , 47 ]. Given the relatively high concentration of zinc, magnesium, calcium and iron found in the sputum of persons with CF and non-CF bronchiectasis [ 48 ], this observation provides a basis for the development of innovative therapeutics and adjunct therapeutics directed against difficult-to-cure NTM pulmonary infections.…”

Section: Discussionmentioning

confidence: 99%

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner

Belardinelli

Martin

et al. 2022

IJMS

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Biofilm growth is thought to be a significant obstacle to the successful treatment of Mycobacterium abscessus infections. A search for agents capable of inhibiting M. abscessus biofilms led to our interest in 2-aminoimidazoles and related scaffolds, which have proven to display antibiofilm properties against a number of Gram-negative and Gram-positive bacteria, including Mycobacterium tuberculosis and Mycobacterium smegmatis. The screening of a library of 30 compounds led to the identification of a compound, AB-2-29, which inhibits the formation of M. abscessus biofilms with an IC50 (the concentration required to inhibit 50% of biofilm formation) in the range of 12.5 to 25 μM. Interestingly, AB-2-29 appears to chelate zinc, and its antibiofilm activity is potentiated by the addition of zinc to the culture medium. Preliminary mechanistic studies indicate that AB-2-29 acts through a distinct mechanism from those reported to date for 2-aminoimidazole compounds.

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Sulfonamides complexed with metals as mycobacterial biofilms inhibitors

Cited by 13 publications

References 31 publications

Septic arthritis in a nonprosthetic joint due to Mycobacterium fortuitum: a case report

Septic arthritis in a nonprosthetic joint due to Mycobacterium fortuitum: a case report

Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner

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