Sulforaphane Modulates Cell Migration and Expression of βCatenin and Epithelial Mesenchymal Transition Markers in Breast Cancer Cells

Bagheri, Minoo; Fazli, Mozhgan; Saeednia, Sara; Kharanagh, Majid Gholami; Ahmadiankia, Naghmeh

doi:10.18502/ijph.v49i1.3054

Cited by 10 publications

(9 citation statements)

References 34 publications

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“…EMT is a key step in tumor cell migration and invasion in various types of human cancer ( 39 – 41 ). Upregulation of N-cadherin induces EMT ( 40 ); another regulator of EMT is E-cadherin, which inhibits the occurrence of EMT and serves as a tumor suppressor ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

“…This indicated that pinosylvin decreased MMP-2 protein expression levels and activity, via regulated the activation of zymogen at the post-transcriptional level. EMT is a key step in tumor cell migration and invasion in various types of human cancer (39)(40)(41). Upregulation of N-cadherin induces EMT (40); another regulator of EMT is E-cadherin, which inhibits the occurrence of EMT and serves as a tumor suppressor (41).…”

Section: Discussionmentioning

confidence: 99%

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Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2

et al. 2021

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Nasopharyngeal carcinoma (NPC) is a tumor located in the nasopharynx with highly invasive and metastatic properties. Metastasis is a primary cause of mortality in patients with NPC. The terpenoid polyphenol pinosylvin is a known functional compound of the Pinus species that exhibits anti-inflammatory effects; however, the effect of pinosylvin on human NPC cell migration and invasion is unclear. The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC-039, NPC-BM and RPMI 2650). Gap closure and Transwell assay indicated that pinosylvin at increasing concentrations inhibited migration and invasion of NPC-039 and NPC-BM cells. In addition to inhibiting the enzyme activity of MMP-2, pinosylvin also decreased the protein expression levels of MMP-2 and MMP-9. Pinosylvin decreased the expression of vimentin and N-cadherin and significantly increased the expression of zonula occludens-1 and E-cadherin in NPC cells. Additionally, pinosylvin suppressed the invasion and migration ability of NPC-039 and NPC-BM cells by mediating the p38, ERK1/2 and JNK1/2 pathways. The present results revealed that pinosylvin inhibited migration and invasion in NPC cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2

et al. 2021

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“…Sulforaphane treatment led to the inhibition of cell proliferation of breast cancer cells lines, MCF-7 and MDA-MB-231 and provoked cytotoxic activity by changing cysteine residues of the promyelocytic leukemia protein, known to promote proliferation of the MCF-7 breast cancer cell line ( Alhazmi et al, 2020 ). Sulforaphane has also been shown to modify cell migration and expression of epithelial mesenchymal transition markers that play a large role in breast cancer metastasis ( Bagheri et al, 2020 ).…”

Section: Glucosinolates From Cruciferous Vegetables and Human Healthmentioning

confidence: 99%

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

et al. 2021

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An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including cardiometabolic, neurological, and musculoskeletal conditions, and certain cancers. A possible protective component, glucosinolates, which are phytochemicals found almost exclusively in cruciferous vegetables, have been identified from preclinical and clinical studies. Current research suggests that glucosinolates (and isothiocyanates) act via several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. This review summarizes the current knowledge surrounding cruciferous vegetables and their glucosinolates in relation to the specified health conditions. Although there is evidence that consumption of a high glucosinolate diet is linked with reduced incidence of chronic diseases, future large-scale placebo-controlled human trials including standardized glucosinolate supplements are needed.

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“…Aiming to assess the effects of SFN in MDA-MB-231 cells, Bagheri et al. ( 52 ) reported that SFN inhibited cells migration starting at the lower concentration of 5 μM, while induced cell apoptosis only at relatively high doses (30 and 40 µM). Additionally, cells treated with SFN exhibited reduced expression of the EMT markers Fibronectin (starting at 20 µM) and ZEB1 (40 µM), and decreased protein accumulation of β-catenin in a time-dependent fashion upon 40 µM SFN treatment ( 52 ).…”

Section: Cancer Stem Cells and Sulforaphanementioning

confidence: 99%

Sulforaphane: An emergent anti-cancer stem cell agent

2023

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Cancer is a major public health concern worldwide responsible for high morbidity and mortality rates. Alternative therapies have been extensively investigated, and plant-derived compounds have caught the attention of the scientific community due to their chemopreventive and anticancer effects. Sulforaphane (SFN) is one of these naturally occurring agents, and studies have shown that it is able to target a specific cancer cell population displaying stem-like properties, known as cancer stem cells (CSCs). These cells can self-renewal and differentiate to form highly heterogeneous tumor masses. Notably, most of the conventional chemotherapeutic agents cannot target CSCs once they usually exist in a quiescent state and overall, the available cytotoxic drugs focus on highly dividing cells. This is, at least in part, one of the reasons why some oncologic patients relapse after standard therapy. In this review we bring together studies supporting not only the chemopreventive and anticancer properties of SFN, but especially the emerging anti-CSCs effects of this natural product and its potential to be used with conventional antineoplastic drugs in the clinical setting.

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Sulforaphane Modulates Cell Migration and Expression of βCatenin and Epithelial Mesenchymal Transition Markers in Breast Cancer Cells

Cited by 10 publications

References 34 publications

Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2

Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

Sulforaphane: An emergent anti-cancer stem cell agent

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