Sulfur-Element containing metabolic pathways in human health and crosstalk with the microbiome

Hansen, Åse; Venkatachalam, K.V.

doi:10.1016/j.bbrep.2023.101529

Cited by 4 publications

(1 citation statement)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such disturbances consequently potentiate neuroinflammatory cascades, impacting the CNS and distal organ systems. This gut-brain crosstalk is particularly germane to a spectrum of disorders, encompassing Alzheimer's Disease, Parkinson's Disease, and Depressive Disorder, and engages mechanisms such as neurotransmitter dysregulation and aberrant immune signaling [133].…”

Section: Nutritional Modulation Via Methionine Restriction and H 2 S ...mentioning

confidence: 99%

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

Munteanu,

Iordan,

Hoteteu

et al. 2023

IJMS

View full text Add to dashboard Cite

In the rapidly evolving field of Alzheimer’s Disease (AD) research, the intricate role of Hydrogen Sulfide (H2S) has garnered critical attention for its diverse involvement in both pathological substrates and prospective therapeutic paradigms. While conventional pathophysiological models of AD have primarily emphasized the significance of amyloid-beta (Aβ) deposition and tau protein hyperphosphorylation, this targeted systematic review meticulously aggregates and rigorously appraises seminal contributions from the past year elucidating the complex mechanisms of H2S in AD pathogenesis. Current scholarly literature accentuates H2S’s dual role, delineating its regulatory functions in critical cellular processes—such as neurotransmission, inflammation, and oxidative stress homeostasis—while concurrently highlighting its disruptive impact on quintessential AD biomarkers. Moreover, this review illuminates the nuanced mechanistic intimate interactions of H2S in cerebrovascular and cardiovascular pathology associated with AD, thereby exploring avant-garde therapeutic modalities, including sulfurous mineral water inhalations and mud therapy. By emphasizing the potential for therapeutic modulation of H2S via both donors and inhibitors, this review accentuates the imperative for future research endeavors to deepen our understanding, thereby potentially advancing novel diagnostic and therapeutic strategies in AD.

show abstract

Section: Nutritional Modulation Via Methionine Restriction and H 2 S ...mentioning

confidence: 99%

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

Munteanu,

Iordan,

Hoteteu

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Discovery of a Gut Bacterial Pathway for Ergothioneine Catabolism

Feng,

Yan,

et al. 2024

J. Am. Chem. Soc.

View full text Add to dashboard Cite

Cellular targets of cytotoxic copper phenanthroline complexes: a multimodal imaging quantitative approach in single PC3 cells

Pinheiro,

Alves,

Matos

et al. 2024

Metallomics

View full text Add to dashboard Cite

Metal complexes are emerging as promising alternatives to traditional platinum-based cancer treatments, offering reduced side effects. However, understanding their cellular uptake and distribution and quantify their presence at the single cell level remains challenging. Advanced imaging techniques, including transmission electron microscopy (TEM), synchrotron radiation X-ray fluorescence (SR-XRF) and energetic ion beam-based nuclear microscopy (STIM, scanning transmission ion microscopy; PIXE, particle-induced X-ray emission; EBS, elastic backscattering spectrometry), allow detailed high-resolution visualization of structure and morphology, high sensitivity for elemental detection with quantification within single cells, and the construction of three-dimensional (3D) models of metal distribution, positioning them as powerful tools for assessing the cellular uptake and compartmentalisation of complexes. Three Cu(II) complexes [Cu(phen)2(H2O)](NO3)2 (1), [Cu(Me2phen)2(NO3)]NO3 (2) and [Cu(amphen)2(H2O)](NO3)2 (3), (phen = 1,10-phenanthroline, Me2phen = 4,7-dimethyl-1,10-phen, amphen = 5-amino-phen) were investigated for Cu uptake and distribution in PC3 prostate cancer cells. All complexes show significant Cu-uptake regardless of media concentration. Cu-concentrations in cytoplasm and nucleus are similar between treatments. Complexes 1 and 3 concentrate Cu in the nuclear region and show a vesicle-like pattern around the nucleus, while 2 shows a dispersed cytoplasmic pattern with large vesicles. The 3D models confirm that Cu is not retained at the plasma membrane, with complex 1 targeting the nucleus and 2 remaining in the cytoplasm. These results highlight the importance of quantifying metal distribution and correlating it with structural changes to understand the relevance of the ligand in the mechanisms of cellular uptake and targeting, crucial for the development of effective metal-based cancer therapies.

show abstract

Sulfur-Element containing metabolic pathways in human health and crosstalk with the microbiome

Cited by 4 publications

References 170 publications

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

Discovery of a Gut Bacterial Pathway for Ergothioneine Catabolism

Cellular targets of cytotoxic copper phenanthroline complexes: a multimodal imaging quantitative approach in single PC3 cells

Contact Info

Product

Resources

About