Sulphetrone: Therapeutics and Toxicology

Abstract

The dis c overy in these laboratories of the chemotherapeutic activity of diaminodiphenysulphone (Buttle et al. I937) stimulateJ a search ' for derivatives having the efficiency of the parent drug " The de:velopment of sulphetrone is part of a programme of work on Antituberculous Com p ounds carried out by the Therapeutic Resenrch Corporation of (;reat Britain.

Are hypersensitivity reactions to dapsone becoming more frequent?

“…Many adverse reactions were encountered in the early use of the suI phones and attempts were made to find a less toxic derivative. 18 The earliest reports of a hypersensitivity reaction to dapsone was published in 1949 based on work in Nigeria. 19 In this early description of the reaction it was thought that dapsone precipitated glandular fe ver.…”