Sulphonamide residues in eggs following drug administration via the drinking water

Roudaut, Brigitte; Garnier, Margaux

doi:10.1080/02652030110102836

Cited by 34 publications

(19 citation statements)

References 15 publications

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“…Antibiotics have been used as growth promoters in the member states of the EU but concerns about development of antibacterial resistance led to the withdrawal of these agents as growth promoters in the EU since January 1, 2006 (Castanon 2007). Some antimicrobial drugs, such as sulphonamides are used to treat coccidiosis (Roudaut and Garnier 2002;Sentepe and Eraslan 2010). In veterinary medicine, the sulphonamides are effective chemotherapeutics for bacterial or protozoal diseases (EMEA 1995;BCFI 2010).…”

Section: Introductionmentioning

confidence: 98%

Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due to cross-contamination of feed

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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Veterinary drugs, such as antimicrobial compounds, are widely used in poultry and may lead to the presence of residues in matrices of animal origin, such as muscle and liver tissue. In this study, broilers received an experimental feed containing sulfadiazine or doxycycline at cross-contamination levels of 2.5, 5 and 10% of the therapeutic dose in feed. Breast and thigh muscle and liver samples were collected during treatment and depletion period and analysed via liquid chromatography-tandem mass spectrometry (LC-MS/MS). Concentrations reached a plateau phase 3-5 days after the start of experimental feeding. A rapid depletion of residues was noted after withdrawal of the experimental feed. No significant differences in measured concentrations were observed between the various muscle types. Residue concentrations for some experimental groups; the 10% group of sulfadiazine and the 5 and 10% group of doxycycline, however, exceeded their corresponding maximum residue limits (MRLs).

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Section: Introductionmentioning

confidence: 98%

Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due to cross-contamination of feed

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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“…Mean recovery was for albumen: SDD 87%, SDMX 77.4% and for Yolk: SDD: 64.6% and SDMX: 67.4%. UV detection at 275 nm yielded LOQ 0.005 mg/g (63).…”

Section: Sulfonamides In Foodstuffs Of Animal Origin 337mentioning

confidence: 99%

Chromatographic Residue Analysis of Sulfonamides in Foodstuffs of Animal Origin

Samanidou

Tolika

Papadoyannis

2008

Separation & Purification Reviews

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The widespread use of antibiotics in veterinary medicine for prophylactic, therapeutic and growth promoting purposes may result in the presence of residues in foodstuff of animal origin. Sulfonamides, N-derivatives of 4-amino-benzenesulfonamide, belong to a diverse class of synthetic antibiotics consisting of chemically related compounds. A number of them e.g., sulfamethazine, sulfadiazine, sulfaquinoxaline and sulfamethoxypyridazine, are widely used in animal husbandry. Their residues in food are of great concern because of their potential carcinogenic character and because they may contribute to the development of antibiotic resistance in humans. These facts have induced most of the regulatory activities on sulfonamides. Regulatory bodies in the European Union as well as in other countries have set different maximum residue limits in various tissues. These regulations have stimulated the development of fast, accurate and sensitive analytical methods for monitoring sulfonamide residues in food samples of animal origin. Gas chromatography methods tend to be timeconsuming due to the required previous cleanup and derivatization procedures, thus, HPLC methods with UV or MS detection have the leading position. These and other aspects of current analytical methodology, including sample preparation and cleanup, are reviewed and discussed. Emphasis is given to confirmatory methods since these comprise useful tools to regulatory agencies, and identifications based on these methods can be used in support of regulatory action.

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“…Different doses and routes of SDD residues have also been studied in laying hens (Blom 1975;Seib 1991;Furusawa 2001;Roudaut and Garnier 2002;Kan 2003). These studies indicated a transfer of sulfonamides into eggs, but mainly provided data on therapeutic doses.…”

Section: Introductionmentioning

confidence: 97%

A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen

Tansakul

Niedorf

Kietzmann

2007

Food Additives and Contaminants

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Low level intake of drugs from the ingestion of contaminated feed may lead to residue problems in food animals. Sulfadimidine (SDD) was used as a model to determine the residue risk at various doses in laying hens. The drug was administered as a single intravenous injection (100 mg kg(-1) body weight, BW), as a single oral dose (100, 30, 10, 3, 1 mg kg(-1) BW) and via medicated feed for 7 consecutive days (30, 10, 3 mg kg(-1) BW). Drug levels were determined with HPLC-UV for plasma, yolk and albumen. Pharmacokinetic values, which were calculated using a first-order one-compartment model, residue levels and transfer rates into the eggs were found to be dose-dependent. Even low doses of 3 and 1 mg kg(-1) BW resulted in measurable residues in yolk and albumen 1 day after a single oral administration. After ingestion of medicated feed at 3 mg kg(-1) BW, mean drug levels at 0.14 +/- 0.01 microg g(-1) were found in albumen and at 0.09 +/- 0.01 microg ml(-1) in plasma. Generally, the residue levels in albumen and plasma were higher than in yolk. These findings demonstrate a residue risk for the consumer even after low level intake of drugs.

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Sulphonamide residues in eggs following drug administration via the drinking water

Cited by 34 publications

References 15 publications

Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due to cross-contamination of feed

Residues of sulfadiazine and doxycycline in broiler liver and muscle tissue due to cross-contamination of feed

Chromatographic Residue Analysis of Sulfonamides in Foodstuffs of Animal Origin

A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen

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