Sumatriptan as a treatment for cyclic vomiting syndrome: A clinical trial

Abstract

We conclude that sumatriptan has potential efficacy in treating of patients with CVS.

Cyclic vomiting syndrome in 28 patients

“…Patients with CVS are usually treated with either antidepressants, antimigrainous or antiepileptic medications [17,[22][23][24]. However, this cohort of patients is unique in that the majority of patients were only treated symptomatically.…”

“…Other drugs used as prophylactic treatment include propranolol [15], phenobarbitone [16] and coenzyme Q [14]. Furthermore, there is evidence for the use of sumatriptan [17] as an acute abortive therapy.…”

Cyclic vomiting syndrome: a case series and review of the literature

“…Treatment should be initiated at the earliest signs of nausea. Sumatriptan (a 5-hydroxytryptamine (HT)- 1 receptor antagonist) has been shown to have some efficacy in aborting the attacks during the prodromal phase,12 when administered, intranasally, subcutaneously or even orally, particularly in patients with a family history of migraine 34 35 49…”

Recent developments in the treatment of migraine in children and adolescents

“…Other triptans have also been studied in the adolescent and Cyclic vomiting syndrome which has been linked to migraine was shown to respond to sumatriptan 3 mg subcutaneously and with a 20 mg nasal spray [17]. Other possibly related migraine disorders have not been studied.…”