Sumatriptan Succinate Loaded Microspheres Containing Compressed Core Tablets for Effective Treatment of Migraine

Abstract

Migraine has long been regarded as a vascular disorder because of the throbbing nature of the pain. Most patients with migraine require pharmacologic treatment. In the present research work sumatriptan succinate is used in the form of compressed core tablets via oral route of administration for effective treatment of migraine. The aim of this study was to reduce the dosing frequency and avoid hepatic first pass metabolism by preparing sumatriptan succinate loaded alginate microsphere. The microspheres were prepared by emulsification method. The prepared microsphere were characterized by scanning electron microscopy, and evaluated for different parameters like particle size, entrapment efficiency, polydispersity index, surface charge and in vitro drug release. The microsphere loaded compressed core tablets were prepared by direct compression method, where the drug loaded microsphere was present in the core of tablet. Further the outer coating layer was applied on the core of tablet that contains plain sumatriptan succinate to immediate release and provides instant relief from migraine symptoms. The formulations were evaluated for various parameters as well as in vitro drug release and compared with plain sumatriptan succinate loaded compressed core tablet. The in vitro drug release showed immediate drug release within 2 min from outer coating layer as well as sustained drug release for up to 24 h from core of tablet. It is concluded that the formulation provide instant as well as delayed release of drug to migraine patient which can decrease the dosing frequency and increase patient compliance.