SUMO Wrestles with Mitophagy to Extend Lifespan

Larrick, James W.; Larrick, Jasmine W; Mendelsohn, Andrew R

doi:10.1089/rej.2020.2406

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…118,119 For instance, silencing of the sole SUMO gene (smo-1) results in a shortened lifespan, while overexpression of smo-1 extends the lifespan in C. elegans. 120 In addition, ribosomes have been shown to play an important regulatory role in proteostasis. 121 A recent study has suggested that as cells age, ribosomal translation "pauses" increase in frequency.…”

Section: Epigenetic Alterationsmentioning

confidence: 99%

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Guo

Huang

Dou

et al. 2022

Sig Transduct Target Ther

480

160

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Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases. Although the development of modern medicine has promoted human health and greatly extended life expectancy, with the aging of society, a variety of chronic diseases have gradually become the most important causes of disability and death in elderly individuals. Current research on aging focuses on elucidating how various endogenous and exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss of proteostasis, compromise of autophagy, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, deregulated nutrient sensing) participate in the regulation of aging. Furthermore, thorough research on the pathogenesis of aging to identify interventions that promote health and longevity (such as caloric restriction, microbiota transplantation, and nutritional intervention) and clinical treatment methods for aging-related diseases (depletion of senescent cells, stem cell therapy, antioxidative and anti-inflammatory treatments, and hormone replacement therapy) could decrease the incidence and development of aging-related diseases and in turn promote healthy aging and longevity.

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Section: Epigenetic Alterationsmentioning

confidence: 99%

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Guo

Huang

Dou

et al. 2022

Sig Transduct Target Ther

480

160

View full text Add to dashboard Cite

show abstract

“…A newly discovered ubiquitin-like molecule, SUMO, can improve stability by modifying proteins. Silencing of SUMO-encoding genes has been found to lead to a reduced lifespan in C. elegans ( 87 , 88 ). In addition, insulin-like growth factor-1 (IGF-1) inhibits the degradation of abnormal proteins by regulating the autophagy–lysosome system and inhibiting lysosomal protein degradation, such as that of the proteasome.…”

Section: Mechanisms Of Ageingmentioning

confidence: 99%

The impact of ageing mechanisms on musculoskeletal system diseases in the elderly

Cai,

Han,

Cheng

et al. 2024

Front. Immunol.

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Ageing is an inevitable process that affects various tissues and organs of the human body, leading to a series of physiological and pathological changes. Mechanisms such as telomere depletion, stem cell depletion, macrophage dysfunction, and cellular senescence gradually manifest in the body, significantly increasing the incidence of diseases in elderly individuals. These mechanisms interact with each other, profoundly impacting the quality of life of older adults. As the ageing population continues to grow, the burden on the public health system is expected to intensify. Globally, the prevalence of musculoskeletal system diseases in elderly individuals is increasing, resulting in reduced limb mobility and prolonged suffering. This review aims to elucidate the mechanisms of ageing and their interplay while exploring their impact on diseases such as osteoarthritis, osteoporosis, and sarcopenia. By delving into the mechanisms of ageing, further research can be conducted to prevent and mitigate its effects, with the ultimate goal of alleviating the suffering of elderly patients in the future.

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