Sumoylation and the oncogenic E17K mutation affect AKT1 subcellular distribution and impact on Nanog-binding dynamics to chromatin in embryonic stem cells

Francia, Marcos; Oses, Camila; Roberti, Sabrina Lorena; Garcia, Mora Reneé; Cozza, Lucas Helio; Diaz, Maria Candelaria; Levi, Valeria; Guberman, Alejandra

doi:10.1016/j.jsb.2023.107961

Journal of Structural Biology

2023

DOI: 10.1016/j.jsb.2023.107961

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Sumoylation and the oncogenic E17K mutation affect AKT1 subcellular distribution and impact on Nanog-binding dynamics to chromatin in embryonic stem cells

Marcos Francia

Camila Oses

Sabrina Lorena Roberti

et al.

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AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts

Francia,

Verneri,

Oses

et al. 2023

BMC Res Notes

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AKT/PKB is a kinase crucial for pluripotency maintenance in pluripotent stem cells. Multiple post-translational modifications modulate its activity. We have previously demonstrated that AKT1 induces the expression of the pluripotency transcription factor Nanog in a SUMOylation-dependent manner in mouse embryonic stem cells. Here, we studied different cellular contexts and main candidates that could mediate this induction. Our results strongly suggest the pluripotency transcription factors OCT4 and SOX2 are not essential mediators. Additionally, we concluded that this induction takes place in different pluripotent contexts but not in terminally differentiated cells. Finally, the cross-matching analysis of ESCs, iPSCs and MEFs transcriptomes and AKT1 phosphorylation targets provided new clues about possible factors that could be involved in the SUMOylation-dependent Nanog induction by AKT.

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AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts

Francia,

Verneri,

Oses

et al. 2023

BMC Res Notes

Self Cite

View full text Add to dashboard Cite

show abstract

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Sumoylation and the oncogenic E17K mutation affect AKT1 subcellular distribution and impact on Nanog-binding dynamics to chromatin in embryonic stem cells

Cited by 1 publication

References 73 publications

AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts

AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts

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