Sun light mediated synthesis of gold nanoparticles as carrier for 6-mercaptopurine: Preparation, characterization and toxicity studies in zebrafish embryo model

Kumar

2017

Asian J Pharm Clin Res

Objective: This study demonstrates a simple, cost-effective protocol for biosynthesis of stable silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) from Hibiscus rosa-sinesis and their comparison by applying antibacterial activities against nine pathogenic bacterial species.Methods: AgNPs and AuNPs were biosynthesized from H. rosa-sinesis. The antibacterial activities of biosynthesized AgNPs (bio-AgNPs) and biosynthesized AuNPs (bio-AuNPs) were evaluated against 9 pathogenic bacterial species Pseudomonas aeruginosa, Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterobacter aerogenes, Escherichia coli, Streptococcus pneumoniae, Aeromonas hydrophila by the agar disc diffusion method.Results: Biological synthesized AgNP/AuNPs were characterized by an ultraviolet-visible (UV-Vis) spectrophotometer, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The existence of silver and gold ions in the extracts was conformed (primary confirmation) through UV-Vis and the maximum plasmon peak was observed at 402 and 530 nm of bio-AgNPs and bio-AuNPs, respectively. Bio-AgNPs were obtained in 13.01-28.14 nm size range, whereas bio-AuNPs were in 6.32-18.19 nm size range after analysis of TEM images. The results of FTIR spectra indicate that the bio-AuNPs were bound to amine groups and bio-AgNPs to carboxylate ion groups. The antibacterial activities of AgNP/AuNP, the zone of inhibition significantly increased with the increases of concentrations of bio-AgNPs in all pathogenic bacterial species except in the case of S. epidermidis at 50%, Streptococcus aerogenes and A. hydrophila at 70%, whereas in the case of bio-AuNPs antibacterial activities were displayed only against B. subtilis at 20% and 100% concentration. Conclusion:This study suggests that AgNPs exhibits outstanding antibacterial activity against pathogenic bacteria as compared to AuNPs synthesized from H. rosa-sinensis leaf extract and insights to their potential applicability as an alternative antibacterial agent in microbial and human health system to reduce the resistance ability of pathogenic bacteria.

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Metal Nanoparticles Synthesized From Hibiscus Rosa Sinesis and Their Antibacterial Activity Estimation Against Nine Pathogenic Bacteria

Kumar

2017

Asian J Pharm Clin Res

“…In this method, HAuCl 4 and aqueous glycine solution was exposed to UVirradiation. Basically amino acid capped gold nanoparticles were used as photochemical initiator which is then further functionalized with glycine [12].…”

Section: Physical Methodsmentioning

confidence: 99%

“…Using of single active substance from plant extract in the synthesis of gold nanoparticles is an important bio synthesis technique to purify gold nanoparticles and to investigate about their medical uses. Gold nanoparticles have been widely used in the field of radiation medicine as radiation enhancer [12] and also provide therapeutic enhancement in radiation therapy due to the efficient and targeted drug delivery to the tumor site. Gold nanoparticles have various applications as platform nanomaterials for biomolecular ultrasensitive detection, killing cancer cells by hyperthermal treatment, labeling for cells and proteins and delivering therapeutic agents within cells.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Ak¹,

Rashid²,

Murtaza³

et al. 2014

Trop. J. Pharm Res

385

163

This review is focused essentially on the synthesis and applications of gold nanoparticles in the field of medicine and targeted drug delivery. Nanotechnology has become one of the most interesting and advanced areas of research in this field. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio.These particles have been widely used in various biomedical applications and drug delivery systems due to their inert nature, stability, high dispersity, non-cytotoxicity and biocompatibility.

International Conference of Recent Trends in Environmental Science and Engineering

“…Based on their various shapes and sizes, they are extensively used in the field of biomedical sciences. Hollow GNPs in the size range of 25 nm are used for cancer therapy [7]; gold nanorods of 2.5 nm are used for drug delivery and photothermal therapy [8]. Gold nanocages are explored extensively in in vivo medical applications [9].…”

Section: Applications Of Gold Nanoparticles In the Field Of Medicinementioning

confidence: 99%

“…GNP's surface plasmon resonance properties enables their efficient use in tumor and in vivo imaging [12], photo thermal therapy [13] and drug delivery [14]. Their efficiency in targeted drug delivery has further been explored in radiation medicine and GNPs are used as radiation enhancers in 103-2 radiation therapy [7]. Taking their drug delivery capability to a step higher, Tang et al, made GNPs-stabilized capsules using an oil core stabilized by amino acids conjugated with cationic GNPs.…”

Section: Applications Of Gold Nanoparticles In the Field Of Medicinementioning

confidence: 99%

Review of Applications and Environmental Fate of Gold Nanoparticles

Palaniappan¹

2018

-The unique properties of nanomaterials do enable them to contribute significantly to environmental protection; however at the same time, they also have a significant negative impact on the environment as well as on living organisms. Among the existing nanomaterials, gold nanoparticle (GNP) is quickly gaining grounds due to its wide ranging uses in the field of medicine, especially radiation therapy and targeted drug delivery. Apparently, the increased production, application and disposal of GNPs have led to an increased release of nanogold into the environment and there are very few studies that bring out the implications of such release. This study aims to review various applications of GNPs and their fate in the environment.