<sup>1</sup>H‐MR spectroscopy and diffusion tensor imaging of normal‐appearing temporal white matter in patients with nasopharyngeal carcinoma after irradiation: Initial experience

Xiong, Wei; Qiu, Shi Jun; Wang, Hong Zhuo; Lv, Xiao Fei

doi:10.1002/jmri.23788

Cited by 43 publications

(58 citation statements)

References 39 publications

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“…In the post-RT-ED group, we have not found significantly changed cortical thickness in the temporal region, but previous DTI studies (Duan et al, 2016, Xiong et al, 2013) have detected abnormal temporal region in the post-RT-ED group. For example, using DTI method, Duan et al (2016) found higher mean diffusivity in the bilateral temporal regions in the post-RT-ED group than that of the pre-RT group.…”

Section: Discussioncontrasting

confidence: 93%

“…And CMBs in the temporal lobe is believed associating with increased likelihood of cognitive dysfunctions in NPC patients after RT (Shen, et al, 2015). Previous studies have found WM alterations in the temporal lobe in the earlier period after RT, including metabolic changes (Xiong, et al, 2013), and abnormalities of water diffusion (Chen, et al, 2015). Actually, brain abnormalities after RT may be multifocal and dispersed throughout GM within the treatment fields (Peterson, et al, 1995), especially in the temporal lobe (Chan, et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy

Lin

Niu

et al. 2017

NeuroImage: Clinical

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Conventional MRI studies showed that radiation-induced brain necrosis in patients with nasopharyngeal carcinoma (NPC) in years after radiotherapy (RT) could involve brain gray matter (GM) and impair brain function. However, it is still unclear the radiation-induced brain morphological changes in NPC patients with normal-appearing GM in the early period after RT. In this study, we acquired high-resolution brain structural MRI data from three groups of patients, 22 before radiotherapy (pre-RT) NPC patients with newly diagnosed but not yet medically treated, 22 NPC patients in the early-delayed stage after radiotherapy (post-RT-ED), and 20 NPC patients in the late-delayed stage after radiotherapy (post-RT-LD), and then analyzed the radiation-induced cortical thickness alteration in NPC patients after RT. Using a vertex-wise surface-based morphometry (SBM) approach, we detected significantly decreased cortical thickness in the precentral gyrus (PreCG) in the post-RT-ED group compared to the pre-RT group. And the post-RT-LD group showed significantly increased cortical thickness in widespread brain regions, including the bilateral inferior parietal, left isthmus of the cingulate, left bank of the superior temporal sulcus and left lateral occipital regions, compared to the pre-RT group, and in the bilateral PreCG compared to the post-RT-ED group. Similar analysis with ROI-wise SBM method also found the consistent results. These results indicated that radiation-induced brain injury mainly occurred in the post-RT-LD group and the cortical thickness alterations after RT were dynamic in different periods. Our findings may reflect the pathogenesis of radiation-induced brain injury in NPC patients with normal-appearing GM and an early intervention is necessary for protecting GM during RT.

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Section: Discussioncontrasting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy

Lin

Niu

et al. 2017

NeuroImage: Clinical

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“…Additionally, the FA values in the right parietal lobe WM markedly decreased in the post-RT 6-12 month group and the values in the right temporal lobe WM markedly decreased after 12 months, compared with that in the pre-RT group. In the late delayed reaction period, as the brain edema was absorbed, the degree of demyelination decreased, myelin regeneration occurred and the FA values in the partial lobe WM recovered gradually (7). In the present study, the FA values in the left parietal lobe and right cerebellar hemisphere WM did not markedly decrease after 6 months and the FA values in right parietal lobe WM did not decrease significantly after 12 months.…”

Section: Mni Coordinate (Mm) ------------------------------contrasting

confidence: 43%

“…Tract-based spatial statistics (TBSS) is a novel processing method of DTI data, with marked advantages compared with the manually drawn regions of interest (ROI) method (10). Previous studies have primarily used the ROI method and have been confined to the temporal lobe (6)(7). To the best of our knowledge, the present study was the first to examine the dynamic alterations in the microstructure of whole brain WM in distinct stages of NPC prior to and following RT, using the TBSS method.…”

Section: Introductionmentioning

confidence: 99%

Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study

et al. 2017

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Abstract. The aim of the present study was to investigate the microstructural characteristics of the brain lobes following radiotherapy (RT) for patients with nasopharyngeal carcinoma (NPC) at distinct times. Diffusion tensor imaging (DTI) and 3D-T1-weighted imaging was performed in 70 age-and sex-matched subjects, 24 of whom were pre-treatment patients. The patients were divided into three groups, according to the time following completion of RT. Fractional anisotropy (FA) and gray matter (GM) volume were determined. The DTI data were analyzed using tract-based spatial statistics and the GM volume was analyzed using voxel-based morphometry (VBM). Compared with the pre-RT group, the mean FA values in the left parietal lobe white matter (WM) and right cerebellum decreased significantly in the post-RT 0-6 month group (P<0.05). In addition, the mean FA values in the right parietal lobe WM decreased significantly in the post-RT 6-12 month group (P<0.05), compared with the pre-RT group. The FA level in the right temporal lobe remained significantly decreased, compared with that in the pre-RT group (P<0.05) for 1 year after RT. Furthermore, compared with pre-RT group, the GM volume in the bilateral frontal lobe, right occipital lobe, left parietal lobe, right temporal lobe and left cerebellum decreased significantly in the post-RT 0-6 month group (P<0.05), and in the bilateral temporal lobe, parietal lobe, right frontal lobe and left cerebellum, the GM volume decreased significantly in the post-RT 6-12 month group (P<0.05). The GM volume in the right temporal lobe, bilateral frontal lobe and bilateral cerebellum remained significantly decreased compared with that in the pre-RT group (P<0.05) for 1 year after RT. A combination of DTI and VBM may be used to determine radiation-induced brain injury in patients treated for NPC.

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“…A recent DTI study found that fractional anisotropy (FA) values showed significant change in different period, these abnormalities were most severe within 6 months after radiotherapy, and different brain regions exhibited distinct rates of recovery thereafter [14]. Furthermore, the indices of DTI have significantly changed in the temporal WM [15,16], as well as regions of normal-appearing WM beyond the target field. To date, for the small-world properties of brain structural networks in NPC patients, few studies focused on the difference between after radiotherapy group and before radiotherapy group.…”

Section: Introductionmentioning

confidence: 99%

Radiation-Induced Changes in Structural Network in Patients with Nasopharyngeal Carcinoma

Tian¹

2017

AJCEM

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Radiation therapy (RT) is the standard radical treatment for nasopharyngeal carcinoma (NPC), and has produced excellent effects in terms of survival rate [1,2]. However, one of the serious complications gave rise by the RT is brain injury. Previous studies have found that RT could cause brain structural abnormalities on gray matter and white matter. Nevertheless, the RT effects on the network level should be further investigated. Herein, we explored changes on the structural network for patients with NPC induced by RT. The structural magnetic resonance data (sMRI) were used to investigate the structural network in 20 NPC patients after and before radiotherapy. After constructing the structural network, we examined the radiation-induced changes in topology properties of small world network using graph theoretical analysis. Our results found that both the before and after radiotherapy groups showed small world properties. Compared with the before radiotherapy (pre-RT) group, the after radiotherapy (post-RT) group had lower global and local efficiency, longer shortest path length, and less clustering coefficient. In addition, the hub regions in the post-RT group were significantly different from the pre-RT group. Our findings exhibited the architecture of network topology and information transfer efficiency became poor in post-RT group. We speculated radiation therapy might induce the differences. The results can provide a new perspective to explore and diagnose radiation-induced brain injury and evaluate the effect of radiotherapy.

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¹H‐MR spectroscopy and diffusion tensor imaging of normal‐appearing temporal white matter in patients with nasopharyngeal carcinoma after irradiation: Initial experience

Abstract: DTI and H(1)-MR spectroscopy can be used to detect early radiation-induced changes of temporal lobe NAWM following radiation therapy for NPC. Metabolic alterations and water diffusion characteristics of temporal lobe NAWM in patients with NPC after RT were dynamic and transient.

Cited by 43 publications

References 39 publications

Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy

Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy

Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study

Radiation-Induced Changes in Structural Network in Patients with Nasopharyngeal Carcinoma

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1H‐MR spectroscopy and diffusion tensor imaging of normal‐appearing temporal white matter in patients with nasopharyngeal carcinoma after irradiation: Initial experience

Abstract: DTI and H(1)-MR spectroscopy can be used to detect early radiation-induced changes of temporal lobe NAWM following radiation therapy for NPC. Metabolic alterations and water diffusion characteristics of temporal lobe NAWM in patients with NPC after RT were dynamic and transient.

Cited by 43 publications

References 39 publications

Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy

Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy

Structural MRI research in patients with nasopharyngeal carcinoma following radiotherapy: A DTI and VBM study

Radiation-Induced Changes in Structural Network in Patients with Nasopharyngeal Carcinoma

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¹H‐MR spectroscopy and diffusion tensor imaging of normal‐appearing temporal white matter in patients with nasopharyngeal carcinoma after irradiation: Initial experience