/sup 131/I tumor quantification: a new background-adaptive method

Koral, Kenneth F.; Dewaraja, Yuni K.; Lin, Shu-Hong

doi:10.1109/nssmic.1997.670515

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…Reasonable accuracy is achieved even with no scatter correction since in this case also a calibration factor that depends on background activity level was used. Therefore, the uncorrected results presented here have been implicitly compensated for scatter to some extent although no actual scatter subtraction was performed [14]. If a constant calibration factor is to be used irrespective of background activity the TEW correction will result in significantly better accuracy over a range of background levels because of the less severe dependence of C F on b (Figure 2).…”

Section: B Lung Phantom Resultsmentioning

confidence: 99%

Quantitative /sup 131/I SPECT with triple energy window Compton scatter correction

Dewaraja

Koral

1998

IEEE Trans. Nucl. Sci.

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In this work accuracy of quantitative l 3 I I SPECT with triple energy window (TEW) scatter correction is evaluated by phantom measurements. The application is tumor imaging of B-cell lymphoma patients treated with l I radioimmunotherapy. The TEW method is a pixel by pixel correction where the scatter fraction in the photopeak window is estimated by linear interpolation between two adjacent narrow sub-windows.For the phantom measurements performed in this work the TEW estimate of scattered counts was close to one half of the total photopeak window counts. Quantification procedure includes marker based X-ray CT-SPECT image fusion to determine object boundaries and to generate attenuation maps.TEW scatter correction significantly reduces the effect of background activity on reconstructed counts within an object, but it still exists due to the finite spatial resolution of the system. Therefore, a background dependent calibration factor had to be used to achieve good quantitative accuracy. Quantitative accuracy with TEW correction was 5% and 14% for a tumor and lung respectively of a physical phantom with non-uniform activity and non-uniform scattering medium. With no scatter subtraction but using a background dependent calibration the quantitative accuracy was 7% and 18% for the tumor and lung respectively.

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Section: B Lung Phantom Resultsmentioning

confidence: 99%

Quantitative /sup 131/I SPECT with triple energy window Compton scatter correction

Dewaraja

Koral

1998

IEEE Trans. Nucl. Sci.

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“…Reasonable accuracy is achieved even with no scatter correction since in this case also a calibration factor that depends on background activity level was used. Therefore, the uncorrected results presented here have been implicitly compensated for scatter to some extent although no actual scatter subtraction was performed [6]. If a constant calibration factor is to be used irrespective of background activity the TEW correction will result in significantly better accuracy over a range of background levels because of the less severe dependence of C F on b (Figure 2).…”

Section: B Lung Phantom Resultsmentioning

confidence: 99%

“…Prior to this work, 1311 scatter correction in our clinic has been done using the dual window or k value method [6]. Unlike the k value method, where a fixed scatter fraction is assumed, the TEW method is a position dependent correction since a scatter fraction is estimated for each pixel.…”

Section: Introductionmentioning

confidence: 99%

Quantitative /sup 131/I SPECT with triple energy window Compton scatter correction

Dewaraja¹,

Li²,

Koral³

1997 IEEE Nuclear Science Symposium Conference Record

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In this work accuracy of quantitative I SPECT with triple energy window (TEW) scatter correction is evaluated by phantom measurements. The TEW method is a pixel by pixel correction where the scatter fraction in the photopeak window is estimated by linear interpolation between two adjacent narrow sub-windows.Quantification procedure includes marker based X-ray CT-SPECT image fusion to determine object boundaries and to generate attenuation maps. TEW scatter correction significantly reduces the effect of background activity on reconstructed counts within an object, but it still exists due to the finite position resolution of the system. Therefore, a background dependent calibration factor was used for quantification. Quantitative accuracy with TEW correction was 5% and 14% for a tumor and lung respectively of a physical phantom with non-uniform activity and non-uniform scattering medium. 0-7803-4258-5/98/$10.00 0 1998 IEEE

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I-131 SPECT activity recovery coefficients with implicit or triple-energy-window scatter correction

Koral

Dewaraja

1999

Nuclear Instruments and Methods in Physics Research Section A:

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/sup 131/I tumor quantification: a new background-adaptive method

Cited by 3 publications

References 5 publications

Quantitative /sup 131/I SPECT with triple energy window Compton scatter correction

Quantitative /sup 131/I SPECT with triple energy window Compton scatter correction

Quantitative /sup 131/I SPECT with triple energy window Compton scatter correction

I-131 SPECT activity recovery coefficients with implicit or triple-energy-window scatter correction

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