Super‐Enhancer–Driven Syndecan‐4 Regulates Intercellular Communication in Hypoxic Pulmonary Hypertension
Xiaoying Wang,
Xiangrui Zhu,
Wei Huang
et al.
Abstract:Background
Unveiling pro‐proliferation genes involved in crosstalk between pulmonary artery endothelial cells and pulmonary artery smooth muscle cells (PASMCs) are important to improving the therapeutic outcome of pulmonary hypertension (PH). Although growing studies have shown that super‐enhancers (SEs) play a pivotal role in pathological and physiological processes, the SE‐associated genes in PH and their impact on PASMC proliferation remain largely unexplored.
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