Supercritical fluid chromatography tandem‐column method development in pharmaceutical sciences for a mixture of four stereoisomers

Barnhart, Wesley W.; Gahm, Kyung H.; Thomas, Sam; Notari, Steve; Semin, David; Cheetham, Janet

doi:10.1002/jssc.200500005

Cited by 37 publications

(21 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[36], the use of coupled columns in SFC analysis was demonstrated to separate four stereoisomers in a mixture (names not specified). Two columns were used, i. e., Chiralcel OD and Chiralpak AD.…”

Section: Separations On Polysaccharide-based Cspmentioning

confidence: 99%

See 1 more Smart Citation

Chiral separations in sub‐ and supercritical fluid chromatography

Mangelings

Heyden²

2008

J of Separation Science

View full text Add to dashboard Cite

show abstract

Section: Separations On Polysaccharide-based Cspmentioning

confidence: 99%

“…Besides the development of the analytical separation of the mixture of four stereoisomers [36] (see Section 2.1.2), the preparative separation of 1 mg mixture was briefly demonstrated, and could be completed within 24 min. Other analysis conditions were a flow rate of 55 mL/min at 408C and 120 bar.…”

Section: Chiral Separations Using Preparative Sfcmentioning

confidence: 99%

Chiral separations in sub‐ and supercritical fluid chromatography

Mangelings

Heyden²

2008

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…First, a wider range of CSPs will be tested, but derivatization of targeted molecule and column coupling can also be envisaged. Recently the SFC coupling of two different chiral columns in series has been reported for the resolution of the four stereoisomers of pharmaceutical compounds containing two chiral centers [168,169].…”

Section: The Domination Of the Polysaccharide Chiral Stationary Phasesmentioning

confidence: 99%

Chiral Recognition Mechanism: Practical Considerations for Pharmaceutical Analysis of Chiral Compounds

2010

Chiral Recognition in Separation Methods

View full text Add to dashboard Cite

“…The recent developments in analytical supercritical fluid chromatography (SFC)-MS as a promising and robust approach for small molecule analysis or purification may provide solutions for some of these issues [32][33][34][35]. Still, further improvements are needed, especially for the analysis of enantiomeric purity and molecular identity.…”

Section: Open-access Analysismentioning

confidence: 99%

MS Applications in Support of Medicinal Chemistry Sciences

Honing¹,

Ingelse²,

Pramanik³

2013

Mass Spectrometry for Drug Discovery and Drug Development

View full text Add to dashboard Cite

In the drug discovery process, medicinal chemistry plays a crucial role in the optimal design and synthesis (production) of new chemical entities (NCEs) or new biological entities (NBEs); this is true for a single entity as well as a complete compound library. A key requirement in this field of science is the optimization of both the chemical and the biological properties of these potential drug-like compounds. Important criteria are the design of efficient synthesis routes, the balancing of the physical chemical properties with optimal in vitro and in vivo drug metabolism and pharmacokinetic (DMPK) processes, and a profound understanding of the pharmacodynamics in the appropriate pharmacological models. In the lead optimization stage, an important step is scaling up the synthesis route as needed for the execution of toxicology studies and the screening of suitable drug formulations. In summary, medicinal chemistry support includes participating in a large variety of activities and decision making processes that play a key role in the search for either a "first in class" new drug or a "best in class" new drug [1].These "drug discovery" processes are continuously under pressure, as the research and development (R&D) costs continue to increase and more data are requested before new drug candidates are taken into (pre-)clinical development. Hence, the choice of "targeted" high-throughput screening (HTS) libraries, the process of hit appraisal, and the understanding of target-ligand interactions can be considered the starting points for a new drug discovery program [2]. Next, the main focus is on the discovery of a lead compound; typically, this is a compound showing promising data regarding target affinity, reasonable efficacy in cellular models, good physical chemical parameters (i.e., a "drug-like" compound), and acceptable oral bioavailability in Mass Spectrometry for Drug Discovery and Drug Development, First Edition. Edited by Walter A. Korfmacher.

show abstract

Supercritical fluid chromatography tandem‐column method development in pharmaceutical sciences for a mixture of four stereoisomers

Cited by 37 publications

References 29 publications

Chiral separations in sub‐ and supercritical fluid chromatography

Chiral separations in sub‐ and supercritical fluid chromatography

Chiral Recognition Mechanism: Practical Considerations for Pharmaceutical Analysis of Chiral Compounds

MS Applications in Support of Medicinal Chemistry Sciences

Contact Info

Product

Resources

About