Superficial Granulomatous Pyoderma: Clinicopathologic Spectrum

Quimby, Steven R.; Gibson, Lawrence E.; Winkelmann, R. K.

doi:10.1016/s0025-6196(12)65301-4

Cited by 58 publications

(47 citation statements)

References 34 publications

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“…528,529 One group has suggested that this condition would be better called 'pathergic granulomatous cutaneous ulceration'. 529,531 The histological changes mimic an infectious process but the lesions respond to corticosteroid therapy and not antibiotics. 529,531 The histological changes mimic an infectious process but the lesions respond to corticosteroid therapy and not antibiotics.…”

Section: Pyoderma Gangrenosummentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Section: Pyoderma Gangrenosummentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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“…It usually does not extend past the underlying adipose tissue, but rare lesions involving the fascia have been reported (1). In contrast, "superficial granulomatous pyoderma" presents with superficial ulcerations that on biopsy demonstrate granulomas, plasma cells, and eosinophils (2)(3)(4)(5).…”

mentioning

confidence: 99%

Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review

Patel¹,

Fitzmaurice²,

Duong³

et al. 2015

Acta Derm Venerol

107

115

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Pyoderma gangrenosum (PG) is an inflammatory disease characterized by painful skin ulcerations with undermined and erythematous borders. The etiology of PG is not well understood, but it is generally considered to be an aberrant immune response characterized by a dermal neutrophilc infiltrate. Given the existence of only a few PG clinical trials, treatment options are largely based upon anecdotal data and small case studies. In addition to classic immunosuppressive medications, PG has been reported to respond well to the anti-TNF agents, infliximab, etanercept, adalimumab. Newer biologics such as ustekinumab (anti-IL-23), ixekizumab (anti-IL-17) and brodalumab (anti-IL-17R) are promising given the effect of IL-17 on neutrophil migration. However, the effectiveness of these newer agents remains to be rigorously evaluated. Multi-drug regimens have not been well described in the literature but are an excellent alternative for patients with refractory disease. Herein, we provide a comprehensive review of the pathophysiology of PG and of the different treatments available for managing PG patients, including the theoretical benefit of initiating multidrug regimens. We also provide one possible treatment algorithm for patients with refractory disease and give examples of refractory PG cases successfully treated with multidrug regimens.

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“…Central cribriform scars and sinus tracts may be recognized.The lesions tended to occur on the sites of trauma, including those of surgical treatment.They tend to occur on the trunk rather than on the extremities in contrast to classic PG. This characteristic pattern of GP was diagnosed as SGP (1) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). In parallel, 13 cases of SGP including our patients have been reported in Japan (15)(16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 71%

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

Kaneko

Tamai

Yamazaki

et al. 2003

The Journal of Dermatology

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Superficial granulomatous pyoderma (SGP) is an unusual variant type of pyoderma gangrenosum characterized by a benign course and specific histological features; it is quite a rare cutaneous disorder in Japan. We reported two Japanese cases of SGP and compared the clinical features of 13 Japanese cases with those of 42 foreign cases. Case 1 was a 53-year-old female who presented with three indolent and ulcerative plaques with elevated edges on the back and the posterior portion of the left thigh. Case 2 was a 74-year-old female who presented with crusted and vegetative erythematous plaques on the left shoulder and left upper arm. Histological examinations revealed a characteristic three-layer granuloma in each case. Laboratory and physical examinations found no abnormalities. Topical corticosteroid, oral administration of minocycline, and/or additional supplementation with corticosteroid were effective. In comparison with foreign cases, Japanese cases show a possible differentiation in the ratio of sex and distribution of the ulcer. Females have a high incidence and the extremities are frequently involved area in Japanese cases. Up to now, 11 cases of SGP have been reported in Japan. To our best knowledge, our patients are the first Japanese cases described in the English literature.

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Superficial Granulomatous Pyoderma: Clinicopathologic Spectrum

Cited by 58 publications

References 34 publications

The granulomatous reaction pattern

The granulomatous reaction pattern

Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

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