Superhydrophobic hemostatic nanofiber composites for fast clotting and minimal adhesion

Li, Zhe; Milionis, Athanasios; Yu, Zheng; Yee, M. Y. Fiona; Codispoti, Lukas; Tan, Freddie; Poulikakos, Dimos; Yap, Choon Hwai

doi:10.1038/s41467-019-13512-8

Cited by 238 publications

(200 citation statements)

References 61 publications

(114 reference statements)

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“…In 2019 Li et al conducted a study of a superhydrophobic hemostatic material made from a nanocomposite dispersion of a dense network of carbon nanofibers and polytetrafluoroethylene (PTFE) or poly-dimethylsiloxane (PDMS) on support [159]. This nanofiber material has been used for its particular and distinctive way of blood coagulation, which allows rapid blood coagulation due to the presence of microfibers and reduces subsequent blood loss, regardless of the pressure applied, due to its superhydrophobic characteristics.…”

Section: Biotechnological and Medical Fieldsmentioning

confidence: 99%

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

et al. 2021

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In recent years, ecological issues have led to the search for new green materials from biomass as precursors for producing carbon materials (CNFs). Such green materials are more attractive than traditional petroleum-based materials, which are environmentally harmful and non-biodegradable. Biomass could be ideal precursors for nanofibers since they stem from renewable sources and are low-cost. Recently, many authors have focused intensively on nanofibers’ production from biomass using microwave-assisted pyrolysis, hydrothermal treatment, ultrasonication method, but only a few on electrospinning methods. Moreover, still few studies deal with the production of electrospun carbon nanofibers from biomass. This review focuses on the new developments and trends of electrospun carbon nanofibers from biomass and aims to fill this research gap. The review is focusing on recollecting the most recent investigations about the preparation of carbon nanofiber from biomass and biopolymers as precursors using electrospinning as the manufacturing method, and the most important applications, such as energy storage that include fuel cells, electrochemical batteries and supercapacitors, as well as wastewater treatment, CO2 capture, and medicine.

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Section: Biotechnological and Medical Fieldsmentioning

confidence: 99%

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

et al. 2021

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“…Li and colleagues designed a hemostatic gauze by using immobilized carbon nanofiber (CNF) [ 35 ]. The CNF coating was fabricated by mixing CNF with polytetrafluoroethylene (PTFE) powder and polydimethylsiloxane (PDMS) respectively.…”

Section: Recent Superhydrophobic Modification On Medical Devicesmentioning

confidence: 99%

Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices

Liew

et al. 2021

IJMS

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Medical devices are indispensable in the healthcare setting, ranging from diagnostic tools to therapeutic instruments, and even supporting equipment. However, these medical devices may be associated with life-threatening complications when exposed to blood. To date, medical device-related infections have been a major drawback causing high mortality. Device-induced hemolysis, albeit often neglected, results in negative impacts, including thrombotic events. Various strategies have been approached to overcome these issues, but the outcomes are yet to be considered as successful. Recently, superhydrophobic materials or coatings have been brought to attention in various fields. Superhydrophobic surfaces are proposed to be ideal blood-compatible biomaterials attributed to their beneficial characteristics. Reports have substantiated the blood repellence of a superhydrophobic surface, which helps to prevent damage on blood cells upon cell–surface interaction, thereby alleviating subsequent complications. The anti-biofouling effect of superhydrophobic surfaces is also desired in medical devices as it resists the adhesion of organic substances, such as blood cells and microorganisms. In this review, we will focus on the discussion about the potential contribution of superhydrophobic surfaces on enhancing the hemocompatibility of blood-contacting medical devices.

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“…[27][28][29][30] Recently, numerous studies have investigated the use of silicones as adhesives and membranes for cutaneous wound treatment:, e.g., state-of-the-art chronic wound dressings and fast clotting dressings. [30][31][32] Extensive research has been conducted on enhancing the properties of silicones to produce improved components for novel wound dressings. [33][34][35] Glycerol-silicone elastomers (GSEs) are two-phase materials originating from the combination of two virtually immiscible liquids into stable emulsions.…”

Section: Introductionmentioning

confidence: 99%

Glycerol–Silicone Membranes for Sustained and Controlled Topical Delivery of Antimicrobial and Pain‐Relief Drugs

Mazurek

Frederiksen

Silau

et al. 2021

Adv Materials Inter

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Controlling drug delivery from medical dressings to wounds remains a challenge despite the presence of multiple drug‐containing wound dressings on the market. The dressing should ideally be effective immediately after application and still show no burst effect, and must also be comfortable for an extended period of time. Here, a silicone‐based membrane is shown to offer an adjustable, constant release of various drugs even at a minimum moisture level resembling that of dry wounds. The drugs are dissolved in glycerol, which is speed‐mixed with silicone and subsequently cured to yield a solid membrane with evenly distributed glycerol microcontainers housing the drug. The drugs are released immediately upon contact with moisture, enabling efficient treatment with short response time and no burst. Drug delivery capability is evaluated using a classical drug release experiment, as well as by performing an antimicrobial susceptibility test on ten bacterial strains in agar diffusion assays. Results show that glycerol–silicone membranes are promising candidates for fighting bacterial infections. Moreover, the addition of glycerol domains to a silicone matrix is proven to have a positive impact on water vapor transmission rate and moisture handling capabilities, resulting in a more skin compliant dressing.

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Superhydrophobic hemostatic nanofiber composites for fast clotting and minimal adhesion

Cited by 238 publications

References 61 publications

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

Electrospun Carbon Nanofibers from Biomass and Biomass Blends—Current Trends

Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices

Glycerol–Silicone Membranes for Sustained and Controlled Topical Delivery of Antimicrobial and Pain‐Relief Drugs

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