Superinfection rate among the patients treated with carbapenem versus piperacillin/tazobactam: Retrospective observational study

Muqati, Hessa Al; Turaiki, Abdulrahman Al; Dhahri, Fahad Al; Enazi, Huda Al; Althemery, Abdullah

doi:10.1016/j.jiph.2020.11.015

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Penggunaan kombinasi antibiotik spektrum luas yang berlebihan dapat meningkatkan risiko terjadinya superinfeksi. 19 Antibiotik golongan β-Lactam adalah golongan antibiotik terbanyak yang digunakan pada penelitian ini, mulai dari penggunaan sebagai terapi tunggal maupun kombinasi. Antibiotik golongan ini memiliki spektrum yang luas sehingga menjadi salah satu pilihan utama dalam terapi CAP.…”

Section: Perpanjangan Rawat Inapunclassified

Kualitas Penggunaan Antibiotik pada Pasien Community-Acquired Pneumonia di Salah Satu Rumah Sakit di Bali

Meriyani,

Sanjaya,

Juanita

et al. 2024

JINTO

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Community-acquired pneumonia (CAP) adalah salah satu penyakit infeksi dengan angka morbiditas dan mortalitas yang tinggi. Antibiotik merupakan salah satu terapi esensial pada CAP yang disebabkan oleh bakteri. Penggunaan antibiotik merupakan salah satu titik kritis dalam pengobatan infeksi, dimana penggunaan antibiotik yang tidak tepat rentan terhadap terjadinya resistensi bakteri terhadap antibiotik. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik pada pasien CAP dan untuk melihat hubungan antara ketepatan penggunaan antibiotik dan penggunaan antibiotik tunggal/ kombinasi dengan perpanjangan rawat inap di salah satu rumah sakit umum di Bali. Penelitian ini merupakan penelitian cross-sectional dengan pengambilan data secara retrospektif di salah satu rumah sakit umum di Bali dengan teknik total sampling. Evaluasi kualitas penggunaan antibiotik dilakukan menggunakan algoritma Gyssens. Hubungan antara ketepatan penggunaan antibiotik dan jenis antibiotik (tunggal/kombinasi) dengan perpanjangan rawat inap dilakukan dengan menggunakan uji Chi-square dengan interval kepercayaan 95%. Terdapat 151 pasien CAP menjadi sampel dalam penelitian ini yang terdiri atas laki-laki 55,63% dan perempuan sebanyak 44,37% dengan median usia 60 tahun (18-89). Sebanyak 17,88% penggunaan antibiotik tepat menurut algoritma gyssens, sedangkan sebanyak 82,18% penggunaan antibiotik tidak tepat. Penggunaan antibiotik yang tidak tepat masuk dalam kategori IIA (tidak tepat dosis) sebanyak 3,97%, kategori IIIB (interval penggunaan tidak tepat) sebanyak 4,64%, kategori IVC (ada alternatif antibiotik yang lebih murah sebanyak 41,72% dan kategori V (tidak sesuai indikasi) sebanyak 37,79%. Tidak terdapat hubungan yang bermakna antara ketepatan penggunaan antibiotik dengan perpanjangan LOS [p>0,05; OR: 1,132 (CI: 0,466-2,746)] namun penggunaan antibiotik (tunggal atau kombinasi) berpengaruh signifikan pada perpanjangan LOS [p<0.05; OR: 0,027 (CI: 0,004-0,204)].

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Section: Perpanjangan Rawat Inapunclassified

Kualitas Penggunaan Antibiotik pada Pasien Community-Acquired Pneumonia di Salah Satu Rumah Sakit di Bali

Meriyani,

Sanjaya,

Juanita

et al. 2024

JINTO

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“…This comes at a cost: broad-spectrum drugs such as the carbapenem class of antibiotics are known for their side effects, mostly due to the elimination of the natural bacterial flora [30][31][32]. Disruption of the delicate balance of organisms that live within us can lead to superinfections, where a single pathogen can take over following antibiotic treatment [33][34][35]. A tailored phage treatment would not eliminate natural flora, as phage specificity could avoid killing beneficial organisms.…”

Section: Broader Applications Of the Viruses Of Bacteriamentioning

confidence: 99%

Flagellotropic Bacteriophages: Opportunities and Challenges for Antimicrobial Applications

Esteves

Scharf

2022

IJMS

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Bacteriophages (phages) are the most abundant biological entities in the biosphere. As viruses that solely infect bacteria, phages have myriad healthcare and agricultural applications including phage therapy and antibacterial treatments in the foodservice industry. Phage therapy has been explored since the turn of the twentieth century but was no longer prioritized following the invention of antibiotics. As we approach a post-antibiotic society, phage therapy research has experienced a significant resurgence for the use of phages against antibiotic-resistant bacteria, a growing concern in modern medicine. Phages are extraordinarily diverse, as are their host receptor targets. Flagellotropic (flagellum-dependent) phages begin their infection cycle by attaching to the flagellum of their motile host, although the later stages of the infection process of most of these phages remain elusive. Flagella are helical appendages required for swimming and swarming motility and are also of great importance for virulence in many pathogenic bacteria of clinical relevance. Not only is bacterial motility itself frequently important for virulence, as it allows pathogenic bacteria to move toward their host and find nutrients more effectively, but flagella can also serve additional functions including mediating bacterial adhesion to surfaces. Flagella are also a potent antigen recognized by the human immune system. Phages utilizing the flagellum for infections are of particular interest due to the unique evolutionary tradeoff they force upon their hosts: by downregulating or abolishing motility to escape infection by a flagellotropic phage, a pathogenic bacterium would also likely attenuate its virulence. This factor may lead to flagellotropic phages becoming especially potent antibacterial agents. This review outlines past, present, and future research of flagellotropic phages, including their molecular mechanisms of infection and potential future applications.

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The quality of antimicrobial prescribing in skin and soft tissue management in Australian hospitals: an analysis of the National Antimicrobial Prescribing Survey data

Park,

Thursky,

Zosky-Shiller

et al. 2024

Journal of Hospital Infection

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Superinfection rate among the patients treated with carbapenem versus piperacillin/tazobactam: Retrospective observational study

Cited by 4 publications

References 15 publications

Kualitas Penggunaan Antibiotik pada Pasien Community-Acquired Pneumonia di Salah Satu Rumah Sakit di Bali

Kualitas Penggunaan Antibiotik pada Pasien Community-Acquired Pneumonia di Salah Satu Rumah Sakit di Bali

Flagellotropic Bacteriophages: Opportunities and Challenges for Antimicrobial Applications

The quality of antimicrobial prescribing in skin and soft tissue management in Australian hospitals: an analysis of the National Antimicrobial Prescribing Survey data

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