2023
DOI: 10.1186/s12951-023-02169-7
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Superior TRAIL gene expression and cancer cell apoptosis mediated by highly branched-linear poly(β-amino ester)s

Yitong Zhao,
Tao Bo,
Chenfei Wang
et al.

Abstract: Extensive efforts have been dedicated to enhancing the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in cancer cells for the development of effective cancer treatments. However, highly safe and efficient delivery of TRAIL gene remains a significant challenge, especially using cationic polymers. Here, a series of highly branched-linear poly(β-amino ester)s (H-LPAEs) are developed through a unique oligomer branching strategy. H-LPAEs exhibit a more uniform distribution of linear s… Show more

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Cited by 6 publications
(1 citation statement)
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“…2c). 42 The optimized H-LPBAEs exhibited enhanced DNA condensation ability, and the positively charged H-LPBAE/DNA complexes demonstrated a high level of gene transfection efficiency in different cell lines. In SW1353 and BMSC cells, the optimized H-LPBAEs achieved 58.0% and 33.4% gene transfection efficiencies, 2.5 and 2.0 times higher than the commercially available gene transfection reagent Lipofectamine 3000, respectively.…”
Section: Strategies To Improve Gene Transfection Efficiencymentioning
confidence: 92%
“…2c). 42 The optimized H-LPBAEs exhibited enhanced DNA condensation ability, and the positively charged H-LPBAE/DNA complexes demonstrated a high level of gene transfection efficiency in different cell lines. In SW1353 and BMSC cells, the optimized H-LPBAEs achieved 58.0% and 33.4% gene transfection efficiencies, 2.5 and 2.0 times higher than the commercially available gene transfection reagent Lipofectamine 3000, respectively.…”
Section: Strategies To Improve Gene Transfection Efficiencymentioning
confidence: 92%