Superior vena cava stenting in IgG4-associated mediastinal fibrosis

Weheba, Ihab; Abdelsayed, Abeer; Zeitouni, Leena; Saleemi, Sarfraz; Mutairy, Eid Al; Hassan, Syed Mujahid

doi:10.5144/0256-4947.2020.155

Cited by 2 publications

(2 citation statements)

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“…IgG4‐RFM is often asymptomatic, but there have been reports of superior vena cava stenosis and tracheal stenosis, which are difficult to treat. 8 , 9 Steroid therapy is effective for IgG4‐RD, and it is important to diagnose IgG4‐RFM in a timely manner and initiate treatment early. Therefore, it is important to determine the presence or absence of IgG4‐RFM within differential diagnoses as well as to keep in mind its characteristic CT imaging findings when conducting differential diagnoses.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, many aspects of the IgG4‐RFM disease manifestation remain unknown. IgG4‐RFM is often asymptomatic, but there have been reports of superior vena cava stenosis and tracheal stenosis, which are difficult to treat 8,9 . Steroid therapy is effective for IgG4‐RD, and it is important to diagnose IgG4‐RFM in a timely manner and initiate treatment early.…”

Section: Discussionmentioning

confidence: 99%

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IgG4‐associated fibrosing mediastinitis requiring differentiation from posterior mediastinal tumour: A case report

Hirai

Iwamoto

Iguchi

et al. 2022

Respirology Case Reports

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A 71‐year‐old man, who was found to have a posterior mediastinal tumour, was referred to our hospital. Contrast‐enhanced computed tomography (CT) showed a 15‐cm soft tissue shadow in the posterior mediastinum, with many affected areas and a gradually increasing pattern. We also detected oligemic areas with poor contrast‐filling. There was no invasion into the adjacent vertebral body and the blood vessels penetrating the interior were intact. Positron emission tomography–CT revealed a high maximum standardized uptake level of 4.53 in the mediastinal masses. We performed thoracoscopic surgery for the biopsy. Histological findings showed lymphoplasmacytic infiltration in the fibrous stroma as well as storiform fibrosis. Immunohistochemical examination revealed abundant infiltration of immunoglobulin G4 (IgG4)‐positive plasma cells and 40% IgG4/IgG‐positive plasma cells. Postoperative serum examinations showed a high serum IgG4 level (570 mg/dl). Accordingly, we diagnosed the patient with IgG4‐related fibrosing mediastinitis, a rare manifestation of IgG4‐related disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%