Superior vena caval syndrome presenting as periorbital edema

Dyken, Jason R.; Pagano, Joseph P.; Soong, Vera Y.

doi:10.1016/s0190-9622(08)81981-0

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…The most frequent include allergic diseases, such as allergic angioedema, urticaria, eczema, conjunctivitis, or insect bites. Further causes include trauma, sinusitis, C1‐esterase inhibitor deficiency, trichinosis, trypanosomiasis, infectious mononucleosis, rosacea, dermatomyositis, Sjögren's syndrome, lupus erythematosus, thyroid diseases, arteritis temporalis, Melkersson–Rosenthal syndrome, amyloidosis, neutrophilic eccrine hidradenitis, sarcoidosis, lymphoma, disseminated intravascular coagulopathy, retroperitoneal leiomyoma, hypervolemia, and hypoproteinemia 1,2 …”

Section: Discussionmentioning

confidence: 99%

Infraorbital eyelid edema as the presenting sign of bronchogenic carcinoma

et al. 2002

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A 59‐year‐old man presented at our department with a 4‐week history of persisting and therapy‐refractory infraorbital edema (Fig. 1). There was no previous history of eyelid edema, allergic reactions, autoimmune diseases, or new medications. Earlier therapy with corticosteroids and antihistamines was ineffective. 1 Persistent swelling of both infraorbital folds The patient suffered from coronary heart disease and long‐standing chronic bronchitis presenting with dyspnea on exertion. He had smoked 50 cigarettes per day since early youth. There was no history of worsening of his bronchogenic symptoms, weight loss, or night sweats over the last 3 months. Initial physical examination revealed marked infraorbital edema, enlarged liver, and decreased breath sounds in the left lung field. Moreover, there was a minor telangiectatic erythema localized to the periumbilical area and to the anterior chest. There was no suffusion of the neck and no remarkable peripheral edema. Laboratory parameters, including electrolytes, blood cell count, creatinine, transaminases, alkaline phosphatase, protein electrophoresis, C1‐esterase inhibitor, C‐reactive protein, immunoglobulin E, and thyroid parameters, were within normal limits. X‐Ray of the chest detected a mediastinal widening. Computed tomography was performed and revealed a mediastinal tumor, 7 cm in diameter, reaching from the aortic arch to the heart. This tumor was compressing the superior vena cava, resulting in stasis of the leading vessels followed by infraorbital edema. Histopathologic examination of tumor biopsies led to the diagnosis of a bronchogenic small‐cell carcinoma. Six cycles of polychemotherapy with doxorubicin, ifosfamide, and vincristine, radiation therapy (50 Gy), and intravascular stenting of the vena cava superior were performed. Following this treatment, regression of the tumor and a distinct decline in infraorbital edema were observed.

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Section: Discussionmentioning

confidence: 99%

Infraorbital eyelid edema as the presenting sign of bronchogenic carcinoma

et al. 2002

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“…The diagnoses are predominantly made by biopsy. Case reports also describe more unusual causes, such as eosinophilic granuloma [73], sarcoid [76], orofacial granulomatosis [82], Kaposi's sarcoma [84], superior vena cava syndrome [86], lymphoma [90], esthesioneuroblastoma [88], and idiopathic orbital inflammation [91]. Eyelid metastasis [89] and hematologic malignancies, such as lymphoma [90] and T-cell prolymphocytic leukemia [77] have been reported to present initially with periorbital swelling.…”

Section: Key Pointsmentioning

confidence: 99%

“…Idiopathic orbital inflammation [78,79] Lupus erythematosus [41,43,47,48] Cold urticaria [49] Melkersson-Rosenthal syndrome [54,55,80,81] Scleredema adultorum of Buschke [58] Allergic eosinophilic gastroenteritis [53] Relapsing polychondritis [50] Orofacial granulomatosis [82] Lymphoma [83] Polyarteritis nodosa [56] Kaposi's sarcoma [84] Protein-losing enteropathy [85] Superior vena cava syndrome [86] Type B Niemann-Pick disease [87] Esthesioneuroblastoma [88] disorder causing periorbital edema in an ophthalmology setting, we performed a retrospective case series at the University of Iowa Hospitals and Clinics Oculoplastics clinic from 2009-2011. Forty patients were referred with the chief complaint of periorbital edema.…”

Section: Retrospective Case Reviewmentioning

confidence: 99%

Periorbital edema

Carter

Allen

2012

Current Opinion in Ophthalmology

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“…In der englischsprachigen Literatur wurde auf dieses in seiner vollen Ausprägung eindrucksvolle Krankheitsbild vor allem in internistisch-onkologischen und seltener in dermatologischen [6,9] Publikationen hingewiesen, während die Bezeichnung VCSS in das deutschsprachige dermatologische Schrifttum bisher unseres Wissens keinen Eingang fand.…”

Section: Fallunclassified

“…In langsam-progredienten Fällen eines VCSS sind oft persistierende Lidschwellungen das Leitsymptom, deren Differentialdiagnose ein weites Spektrum von lokalen und systemischen Ursachen umfaßt [6,12]. Die Lidregion ist aufgrund der lockeren Gewebetextur für die Ansammlung interzellulärer Ödemflüssigkeit prädisponiert, allerdings kann eine Lidschwellung auch durch eine lokale Infiltration bzw.…”

Section: Klinische Symptomatikunclassified

Das Vena-cava-superior-Syndrom

et al. 1997

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Superior vena cava syndrome (VCSS) develops because of a progressive reduction of venous return from the head, neck and the upper extremities. The presenting sign of this relatively rare condition is often a rapidly developing, often massive facial edema. As a consequence, such the patients are often seen initially by a dermatologist. Other clinical characteristics may include cyanotic facial erythema, dilatation of the neck veins, and a prominent venous pattern n the anterior chest. Today, primary lung cancers and other mediastinal tumours represent the most common cause of VCSS, which may take a slowly progressive or a more fulminant course. In these cases, the disease develops rapidly and becomes life-threatening, requiring intensive medial diagnosis and care. We describe three patients with superior vena cava syndrome due to a) bronchogenic carcinoma, b) bihilar sarcoidosis and c) metastasizing malignant melanoma. Since recognition of VCSS broadens the diagnostic spectrum of the dermatologist, an overview on its diagnostic and therapeutic implications is given based on our cases and the literature.

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Superior vena caval syndrome presenting as periorbital edema

Cited by 18 publications

References 25 publications

Infraorbital eyelid edema as the presenting sign of bronchogenic carcinoma

Infraorbital eyelid edema as the presenting sign of bronchogenic carcinoma

Periorbital edema

Das Vena-cava-superior-Syndrom

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