Superoxide dismutase activity in children with chronic liver diseases

Broide, Efrat; Klinowski, Elieser; Koukoulis, George Κ.; Hadžić, Nedim; Portmann, B; Baker, Alastair; Scapa, Eitan; Mieli‐Vergani, Giorgina

doi:10.1016/s0168-8278(00)80062-8

Cited by 27 publications

(20 citation statements)

References 29 publications

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“…Therefore, the production of free radicals, such as injurious hydroxyl free radicals, might lead to the deterioration of hepatic function [5,11]. After activating the stellar cells in response to oxidative stress and breaking the balance between extracellular matrix synthesis and decomposition with TGF-beta1 over production, hepatic fibrosis is likely to advance [15][16][17]. In addition to the conventional parameters of liver function, parameters of oxidative stress above described might be important and useful in the appropriate follow-up of the post-operative patients with BA.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress profile in the post-operative patients with biliary atresia

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Oxidative stress profile in the post-operative patients with biliary atresia

et al. 2008

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“…The changes in the activity of antioxidant enzymes, such as SOD, CAT and GST-Px, were examined in children with liver diseases. Chrobot et al (12) observed a statistically significant decrease of CAT and SOD activities and a decrease in GSH-Px activity in children with chronic hepatitis B and C. In the case of infants with cholestatic liver disease due to bile duct damage and children with portal vein thrombosis, the SOD activity was increased (13). A decreased GSH level in chronic liver diseases has been reported in many reports (6,14).…”

Section: Introductionmentioning

confidence: 92%

Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders

Baltruskeviciene¹,

Kazbarienė²,

Badaras³

et al. 2016

Turk J Gastroenterol

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“…They suggested that the reduction in the hepatic antioxidant defense system, such as SOD and catalase, could contribute to the development of liver injury through an Chu/Lee-Kang/Lee/Lee enhancement of hepatic lipid peroxidation. In contrast, some groups reported that SOD is increased significantly in the liver tissue with cholestatic liver disease [33]. Although products of the ROS reactions are involved in the pathogenesis of cholestatic liver disease, the concentrations and the roles of antioxidants including SOD and catalase in cholestasis are still controversial.…”

Section: Antioxidants Levels For Sod Catalase Prx I and Prx Iimentioning

confidence: 98%

Roles of Reactive Oxygen Species, NF-κB, and Peroxiredoxins in Glycochenodeoxycholic Acid-Induced Rat Hepatocytes Death

Chu

Lee-Kang²,

Lee

et al. 2003

Pharmacology

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The aim of this study was to determine the roles of reactive oxygen species (ROS), NF-ĸB and antioxidants in glycochenodeoxycholic acid (GCDC, 0–400 µmol/l, 0.5– 3 h)-induced hepatocytes death. The differential uptake of ethidium bromide and acridine orange revealed that apoptotic death occurred dose-dependently in GCDC-treated hepatocytes whereas necrotic death was prominent especially at higher GCDC concentrations (≧200 µmol/l). ROS generation measured fluorometrically either by a confocal laser microscope or by a microplate fluorescence reader was increased dose-dependently. The dose-dependent NF-ĸB activation with the significant IĸB-α decrease preceded both hepatocyte cell death and the alteration of antioxidant enzymes. The Cu/Zn-SOD level among several antioxidants, we checked, remained unchanged. In contrast, the catalase level and its enzymatic activity were markedly decreased only at 400 µmol/l. The Prx I and Prx II, newly defined antioxidant enzymes reducing H₂O₂ levels were decreased at the 200 and 400 µmol/l. These observations point to ROS generation in the GCDC-treated hepatocyte as the proximate event that triggers NF-ĸB activation, IĸB-α proteolysis, Prx depletion, and finally cell death. And oxidative stress may be more related to necrotic cell death in GCDC-treated hepatocytes.

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Superoxide dismutase activity in children with chronic liver diseases

Cited by 27 publications

References 29 publications

Oxidative stress profile in the post-operative patients with biliary atresia

Oxidative stress profile in the post-operative patients with biliary atresia

Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders

Roles of Reactive Oxygen Species, NF-κB, and Peroxiredoxins in Glycochenodeoxycholic Acid-Induced Rat Hepatocytes Death

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