Superoxide dismutase, glutathione peroxidase and catalase in the red cells of patients with malignant lymphoma

Bewick, M.; Coutie, Wendy J.; Tudhope, G. R.

doi:10.1111/j.1365-2141.1987.tb06866.x

Cited by 43 publications

(18 citation statements)

References 14 publications

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“…Similar observations have previously been stated in different studies related to free radical levels in thyroid cancer, hepatoma and lymphoma. [8][9][10] Ray et al in their study on breast cancer demonstrated high levels of MDA in females with breast cancer (12.87 ± 4.13 µM/ml) as compared to control (10.21± 2.91 µM/ml) and the difference was found to be statistically significant (p<0.005). [11] We also discovered that the levels of MDA are higher in females suffering from breast cancer as compared to the control group consisting of benign breast disease patients.…”

Section: Discussionmentioning

confidence: 71%

Implications of free radicals and antioxidant levels in carcinoma of the breast: A never-ending battle for survival

2009

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Background: Under normal circumstances, there is a steady balance between the production of oxygen derived free radicals and their destruction by the cellular antioxidant system inside the human body. However, any imbalance between the levels of these oxidants and antioxidants might cause DNA damage and may lead to cancer development. The aim of this study was to evaluate the level of antioxidants and free radicals in blood and tissue of cancer patients and compare these levels at different TNM stages to derive the possible role of free radicals and antioxidant enzymes in the etiology of breast cancer. Materials and Methods: This study includes 30 patients suffering from cancer breast and 20 patients as controls who had benign breast diseases. Circulating lipid peroxide (Malonyldialdehyde [MDA]) levels and activities of the defensive enzymes (Superoxide Dismutase [SOD] and Catalase [CAT]) were estimated in the blood and breast tissue of these patients. Results: Increased levels of free radicals and low levels of antioxidants were observed in malignant tissue. An elevated lipid peroxide concentration was found in the tissue of all the cancer breast patients as evidenced by an increase in the mean MDA level seen with increasing TNM stage of carcinoma breast. Levels of antioxidants SOD and CAT were decreased in cancer patients. Conclusion: The results of our study suggest that free radical activity is enhanced in cancer breast patients while the antioxidant defense mechanism is weakened. This activity is enhanced with the increasing severity of cancer as depicted in different TNM stages of breast cancer.

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Section: Discussionmentioning

confidence: 71%

Implications of free radicals and antioxidant levels in carcinoma of the breast: A never-ending battle for survival

2009

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“…CYBA encodes the small sub-unit, p22-phox protein, of the cytochrome b 558 of the NADPH oxidase that plays a crucial role in NADPH-dependent ROS production. Endogenous defenses against ROS formation and genomic damage includes superoxide dismutase enzymes, glutathione peroxidase, as well as myeloperoxidase (Bewick 1987). Superoxide dismutase converts superoxides into hydrogen peroxide, and glutathione peroxidase converts hydrogen peroxide into water.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma

et al. 2006

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Oxidative damage caused by reactive oxygen species (ROS) and other free radicals is involved in a number of pathological conditions including cancer. In a population-based case-control study of non-Hodgkin lymphoma (NHL) (n = 518 cases, 597 controls) among women in Connecticut, we analyzed one or more single nucleotide polymorphisms (SNPs) in ten candidate genes (AKR1A1, AKR1C1, AKR1C3, CYBA, GPX1, MPO, NOS2A, NOS3, OGG1, and SOD2) that mediate oxidative stress directly or indirectly in the NADPH oxidase-dependent respiratory burst. Odds ratios (OR) and 95% conWdence intervals (CI) were adjusted for age and race. Polymorphisms in AKR1A1 and CYBA were signiWcantly associated with increased risk of NHL. There was a 1.7-fold (95% CI = 1.2-2.4, P = 0.0047) increased risk of NHL for individuals who were variant homozygous for the AKR1A1 (IVS5 + 282T > C) SNP. The eVect was most pronounced for risk of diVuse large B-cell lymphoma, but risk estimates were non-signiWcantly elevated for other common B-cell histologies and T-cell lymphomas as well. In addition, individuals variant homozygous for the CYBA (Ex4 + 11C > T) SNP had a 1.6-fold (95% CI = 1.1-2.4, P = 0.019) increased risk of NHL that was particularly pronounced for T-cell lymphoma (OR = 3.5, 95% CI = 1.3-9.6, P = 0.013), but was also associated with non-signiWcant increased risks for each of the common B-cell histologies. These results suggest that SNPs in genes related to the oxidative stress pathway may be associated with increased risk of NHL.

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“…[16] In order to provide protection against free oxygen radicals, erythrocytes are well equipped with antioxidant defense enzymes, such as catalase, SOD, and GPX. [17][18][19] It has been reported that catalase activity is significantly reduced in cancer patients. [20] Treatment with chemotherapeutic drugs, including CPA, further reduces this activity, [6] which makes the system inefficient to scavenge free radicals.…”

Section: Resultsmentioning

confidence: 99%

Effect of Millimeter Wave Radiation on Catalase Activity

Logani¹,

Agelan

Ziskin³

2002

Electromagnetic Biology and Medicine

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Millimeter wave therapy has been reported to reduce the toxic side effects of chemo-and radiation therapy in the treatment of cancer. In order to understand the mechanisms involved in this reduction, the effect of millimeter electromagnetic waves (MWs) on catalase activity was examined in mouse blood. SKH-1 hairless mice were irradiated on their midbacks with 42.2 ± 0.2 GHz millimeter waves. The incident power density used was 31 ± 5 mW/cm 2 and the peak SAR was 622 ± 100 W/kg as measured using infrared thermography. The animals were irradiated before or after administration of cyclophosphamide (CPA), an anticancer drug. The sham control groups were treated in a similar manner, but not irradiated. MW irradiation, before or after administration of CPA did not significantly reduce the toxic effect of CPA on catalase activity in mouse blood.

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Superoxide dismutase, glutathione peroxidase and catalase in the red cells of patients with malignant lymphoma

Cited by 43 publications

References 14 publications

Implications of free radicals and antioxidant levels in carcinoma of the breast: A never-ending battle for survival

Implications of free radicals and antioxidant levels in carcinoma of the breast: A never-ending battle for survival

Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma

Effect of Millimeter Wave Radiation on Catalase Activity

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