Superoxide Dismutase (SOD) Level in Blood of the People Living in High and Lowest Radon Exposure Area: A Study in Padalarang, West Java Indonesia

Abstract

Abstract:Radon 222 released from rocks contribute to the level of radiation in human body. The stratigraphy of West Java, which is dominated by granite, has a high level of radon. The result of the study in Padalarang shows that the highest dose of radon is 24 Bq/kg and the lowest 17 Bq/kg. The alpha rays may affect the Superoxide Dismutase (SOD) level. The research is conducted on all men and women in the age of 30 to 70 living in Padalarang district who met the inclusion criteria, with good general health condition, being original inhabitant since birth, not suffering from chronic systemic infectious diseases, and willing to participate in the research by completing the informed consent. Sample is taken by using consecutive sampling. Blood sample is taken as much as 2 cc/person by using a 2cc syringe, which is then inserted into venoject tube containing heparin. Antioxidant activity in the blood plasma is examined by using SOD Kit. The average of SOD level is 3.56 ui/ml in Highland (Masigit Mountain) and 1.65ui/ml in lowland (Cipatat). The increase of SOD level of the people living in Highland is suspected to be the contribution of radon exposure contained in rocks and water.

Priming Low-Dose Gamma Irradiation Increases Cellular Radioadaptation Response through the Induction of Hsp70 and SOD2

“…SOD2 (Mn-SOD) is one of the important cytoprotectors. MnSOD is essential for the survival of all aerobic organisms, and it contributes to the development of cellular resistance to ROS (oxidative stress condition) [7]. SOD2 catalyzes the dismutation of superoxide radicals into hydrogen peroxide and oxygen.…”

“…Hsp70 is a protein that has an important role in protein folding or preventing protein misfolding due to heat and other stresses including oxidative stress due to accumulation of reactive oxygen species (ROS) [6]. Meanwhile, SOD, especially SOD2, is the first line of antioxidant enzymatic defenses that play an important role in preventing the accumulation of ROS [7]. SOD is the most common enzymatic antioxidant which converts superoxide into hydrogen peroxide (H 2 O 2 ) in mitochondria and cytosol [3], so that the formation of • OH radicals can be prevented.…”

Dosis Rata-Rata Harian dan Efektif Tahunan Radon Airtanah pada Daerah Gunung Masigit, Kecamatan Cipatat, Kabupaten Bandung Barat, Indonesia

“…Pada penelitian di daerah yang sama dengan kandungan konsentrasi yang berbeda memperlihatkan perbedaan kondisi kesehatan rongga mulut level antioksidan (Azhari et al, 2016;Permatasari et al, 2017). Pada kasus kandungan Radon konsentrasi tinggi seperti di Ramsar, Iran terjadi peningkatan dosis photon dan elektron yang mempengaruhi dosis efektif tahunan (Banari Bahnamiri, 2015;Monfared et al, 2013).…”