Superoxide radical as electron donor for oxidative phosphorylation of ADP

Mailer, Kathleen

doi:10.1016/0006-291x(90)91240-s

Cited by 51 publications

(26 citation statements)

References 11 publications

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“…ROS released into the mitochondrial matrix is therefore neutralized by MnSOD (100). The fate of O 2 ·− in the IMS is short lived, as the superoxide anion within IMS may be quickly inactivated by Cu/ZnSOD which has been described in the IMS (101), or by cytochrome c which can be directly reduced by O 2 −· and subsequently pass electrons to complex IV (102). H 2 O 2 is detoxified by the enzyme catalase.…”

Section: Ca2+ and Mitochondrial Reactive Oxygen Speciesmentioning

confidence: 99%

Crosstalk signaling between mitochondrial Ca2+ and ROS

Feissner

Skalska²,

Gaum³

et al. 2009

Front Biosci

375

280

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Mitochondria are central to energy metabolism as the source of much of the cell’s ATP, as well as being a hub for cellular Ca2+ signaling. Mitochondrial Ca2+ is a positive effector of ATP synthesis, yet Ca2+ overload can lead to mitochondrial dysfunction and cell death. Moreover, Ca2+ uptake by mitochondria is involved in shaping cellular Ca2+ dynamics by regulating the concentrations of Ca2+ within microdomains between mitochondria and sarco/endoplasmic reticulum and plasma membrane Ca2+ transporters. Reactive oxygen species (ROS) generated as a consequence of ATP production in the mitochondria are important for cellular signaling, yet contribute to oxidative stress and cellular damage. ROS regulate the activity of redox sensitive enzymes and ion channels within the cell, including Ca2+ channels. For both Ca2+ and ROS, a delicate balance exists between the beneficial and detrimental effects on mitochondria. In this review we bring together current data on mitochondrial Ca2+ uptake, ROS generation, and redox modulation of Ca2+ transport proteins. We present a model for crosstalk between Ca2+ and ROS signaling pathways within mitochondrial microdomains.

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Section: Ca2+ and Mitochondrial Reactive Oxygen Speciesmentioning

confidence: 99%

Crosstalk signaling between mitochondrial Ca2+ and ROS

Feissner

Skalska²,

Gaum³

et al. 2009

Front Biosci

375

280

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“…There is much evidence for the formation of the ADP radical molecule (Moorthy et al 1975;Sevilla et al 1976;Scheek et al 1981;Losinova et al 1986;Mailer 1990). The participation of this radical in a riboflavin-sensitized phosphorylation of ADP by orthophosphate in aqueous solution was considered and experimentally substantiated (Losinova et al 1983(Losinova et al , 1986Nedelina 1997).…”

Section: Discussionmentioning

confidence: 95%

Abiogenic Photophosphorylation of ADP to ATP Sensitized by Flavoproteinoid Microspheres

Телегина

Lyudnikova

Kritsky

2008

Orig Life Evol Biosph

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A model for abiogenic photophosphorylation of ADP by orthophosphate to yield ATP was studied. The model is based on the photochemical activity of flavoproteinoid microspheres that are formed by aggregation in an aqueous medium of products of thermal condensation of a glutamic acid, glycine and lysine mixture (8:3:1) and contain, along with amino acid polymers (proteinoids), abiogenic isoalloxazine (flavin) pigments. Irradiation of aqueous suspensions of microspheres with blue visible light or ultraviolet in the presence of ADP and orthophosphate resulted in ATP formation. The yield of ATP in aerated suspensions was 10-20% per one mol of starting ADP. Deaeration reduced the photophosphorylating activity of microspheres five to 10 times. Treatment of aerated microsphere suspensions with superoxide dismutase during irradiation partially suppressed ATP formation. Deaerated microspheres restored completely their photophosphorylating activity after addition of hydrogen peroxide to the suspension. The photophosphorylating activity of deaerated suspensions of flavoproteinoid microspheres was also recovered by introduction of Fe3+-cytochrome c, an electron acceptor alternative to oxygen. On the basis of the results obtained, a chemical mechanism of phosphorylation is proposed in which the free radical form of reduced flavin sensitizer (F1H*) and ADP are involved.

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“…In contrast, oxidation of cytochrome c by cytochrome c oxidase generates protonmotive force that mitochondria can use to produce ATP, as was demonstrated in experiments with heart mitochondria exposed to the exogenously generated superoxide. 123 …”

Section: Cytochrome Cmentioning

confidence: 97%