Superparamagnetic graphene oxide–Fe3O4 nanoparticles hybrid for controlled targeted drug carriers

Abstract

A superparamagnetic graphene oxide -Fe 3 O 4 nanoparticles hybrid (GO-Fe 3 O 4 ) was prepared via a simple and effective chemical precipitation method. The amount of loading of Fe 3 O 4 on GO was estimated as 18.6 wt% by atomic absorption spectrometry. The hybrid was then loaded with doxorubicin hydrochloride (DXR) and the loading capacity was as high as 1.08 mg mg À1 . Both of the GO-Fe 3 O 4 hybrids before and after loading with DXR can be dispersed well in aqueous solution. They can congregate under acidic conditions and move regularly under the force of an external magnet. Furthermore, the aggregated hybrid can be redispersed to form a stable suspension under basic conditions. These properties make it a potential candidate for controlled targeted drug delivery and release.

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

“…Previously, we have demonstrated that antibody functionalized SWCNTs possess expected adsorption capacity and release performance for Dox [34]. The loading and release performances of the FA-MWCNT@Fe nanocarriers were investigated and compared with a commonly used magnetic carrier, Fe 3 O 4 NPs [45][46][47].…”

Synergistic Enhancement in Catalytic Performance of Superparamagnetic Fe3O4@Bacilus subtilis as Recyclable Fenton-Like Catalyst

“…In addition, another challenge that impedes the practical application of Fe 3 O 4 is the production of iron-containing waste sludge, which introduces secondary pollution [7,8]. Hence, to overcome these disadvantages, significant efforts have been made to immobilize the Fe 3 O 4 particles onto various support materials, simultaneously preserving their unique magnetic property [9][10][11][12].…”

Hybrid Nanomaterials of Magnetic Iron Nanoparticles and Graphene Oxide as Matrices for the Immobilization of β-Glucosidase: Synthesis, Characterization, and Biocatalytic Properties

“…The functionalization of magnetic nanoparticles with carbon-based nanomaterials has recently attracted great interest as the resulting hybrid nanomaterials combine the properties of both building blocks. These hybrids can be applied in enzyme immobilization (Jiang et al, 2012;Gokhale et al, 2013) as well as in drug delivery (Yang et al, 2009;Mahmoudi et al, 2011).…”