Superparamagnetic iron oxide nanoparticles based cancer theranostics: A double edge sword to fight against cancer

Ansari, Mohd Owais; Ahmad, Fahim; Shadab, G. G. H. A.; Siddique, Hifzur R.

doi:10.1016/j.jddst.2018.03.017

Cited by 46 publications

(33 citation statements)

References 100 publications

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“…ION systems have been widely employed for cancer theranostic applications due to their promising potential as MRI contrast agents for cancer diagnosis, drug delivery vehicles for chemotherapy, and intracellular hyperthermia treatments [ 182 ]. Moreover, due to the marked phenotype differences between carcinogenic and healthy cells, overexpressed receptors in cancer cells serve as exceptional targets for targeted delivery of IONs.…”

Section: Enhancing Ion Internalizationmentioning

confidence: 99%

Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

et al. 2020

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Iron oxide nanoparticles (IONs) have been widely explored for biomedical applications due to their high biocompatibility, surface-coating versatility, and superparamagnetic properties. Upon exposure to an external magnetic field, IONs can be precisely directed to a region of interest and serve as exceptional delivery vehicles and cellular markers. However, the design of nanocarriers that achieve an efficient endocytic uptake, escape lysosomal degradation, and perform precise intracellular functions is still a challenge for their application in translational medicine. This review highlights several aspects that mediate the activation of the endosomal pathways, as well as the different properties that govern endosomal escape and nuclear transfection of magnetic IONs. In particular, we review a variety of ION surface modification alternatives that have emerged for facilitating their endocytic uptake and their timely escape from endosomes, with special emphasis on how these can be manipulated for the rational design of cell-penetrating vehicles. Moreover, additional modifications for enhancing nuclear transfection are also included in the design of therapeutic vehicles that must overcome this barrier. Understanding these mechanisms opens new perspectives in the strategic development of vehicles for cell tracking, cell imaging and the targeted intracellular delivery of drugs and gene therapy sequences and vectors.

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Section: Enhancing Ion Internalizationmentioning

confidence: 99%

Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

et al. 2020

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) have several advantages, as they can be used in magnetic resonance imaging, cell labeling, tissue targeting, hyperthermia, and drug delivery [74]. In nature, SPIONs are frequently found in different forms, such as hematite (α-Fe 2 O 3 ), maghemite (γ-Fe 2 O 3 ), and magnetite (Fe 3 O 4 ), among others.…”

Section: Superparamagnetic Iron Oxide Nanoparticlesmentioning

confidence: 99%

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics—A Critical Review

Diogo

Faustino

Neves

et al. 2019

JFB

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Apical periodontitis is a biofilm-mediated disease; therefore, an antimicrobial approach is essential to cure or prevent its development. In the quest for efficient strategies to achieve this objective, antimicrobial photodynamic therapy (aPDT) has emerged as an alternative to classical endodontic irrigation solutions and antibiotics. The aim of the present critical review is to summarize the available evidence on photosensitizers (PSs) which has been confirmed in numerous studies from diverse areas combined with several antimicrobial strategies, as well as emerging options in order to optimize their properties and effects that might be translational and useful in the near future in basic endodontic research. Published data notably support the need for continuing the search for an ideal endodontic photosensitizer, that is, one which acts as an excellent antimicrobial agent without causing toxicity to the human host cells or presenting the risk of tooth discoloration. The current literature on experimental studies mainly relies on assessment of mixed disinfection protocols, combining approaches which are already available with aPDT as an adjunct therapy. In this review, several approaches concerning aPDT efficiency are appraised, such as the use of bacteriophages, biopolymers, drug and light delivery systems, efflux pump inhibitors, negative pressure systems, and peptides. The authors also analyzed their combination with other approaches for aPDT improvement, such as sonodynamic therapy. All of the aforementioned techniques have already been tested, and we highlight the biological challenges of each formulation, predicting that the collected information may encourage the development of other effective photoactive materials, in addition to being useful in endodontic basic research. Moreover, special attention is dedicated to studies on detailed conditions, aPDT features with a focus on PS enhancer strategies, and the respective final antimicrobial outcomes. From all the mentioned approaches, the two which are most widely discussed and which show the most promising outcomes for endodontic purposes are drug delivery systems (with strong development in nanoparticles) and PS solubilizers.

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“…This material has been applied in drug delivery systems, magnetic fluid hyperthermia (MFH) [4,5] and contrast agent for magnetic resonance imaging [6]. Theranostics systems, whose diagnosis and treatment are carried out on a single platform, has also been investigating [7,8].…”

Section: Introductionmentioning

confidence: 99%

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

Piazza

Viali

Santos

et al. 2020

Mater. Res. Express

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Superparamagnetic iron oxide nanoparticles (SPION) are of great interest for application in magnetic fluid hyperthermia (MFH) due to their heat generation capability in an external alternating magnetic field, besides biocompatibility, and surface properties. MFH has emerged as a promisor therapeutic approach for cancer treatment and is based in controlled heating tumor tissue through the accumulation of SPIONs within cancer cells. This work describes a new route for the preparation of folate-conjugated PEGylated SPIONs, which involves the attachment of such molecules at the surface through polycondensation reactions, without the need for coupling agents or prior modification on the species involved. The size of iron oxide cores obtained by transmission electron microscopy was about 12 nm. The conjugation of folate onto SPIONs was confirmed by FTIR spectroscopy. The folate conjugated nanoparticles were colloidal stable in PBS, presenting a hydrodynamic diameter of 109±1 nm and PDI 0.148. The obtained folate-targeted PEGylated SPIONs showed superparamagnetic behavior with a saturation magnetization of 73.1 emu·g −1 at 300 K. Their specific absorption rate (SAR) ranged from 32.8 to 15.0 W g −1 in an alternating magnetic field of 10-16 kA m −1 and frequency of 420-203 kHz. The heat generated was sufficient to raise the sample temperature to the therapeutic range used in MFH establishing this system as promising candidates for use in MFH treatment.

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Superparamagnetic iron oxide nanoparticles based cancer theranostics: A double edge sword to fight against cancer

Cited by 46 publications

References 100 publications

Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics—A Critical Review

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

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