Superparamagnetic magnetite nanocrystal clusters as potential magnetic carriers for the delivery of platinum anticancer drugs

Xing, Ruimin; Wang, Xiaoyong; Zhang, Changli; Wang, Jinzhuan; Zhang, Yangmiao; Song, You; Guo, Zijian

doi:10.1039/c1jm11369k

Cited by 67 publications

(34 citation statements)

References 44 publications

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“…152–166 Although several of these constructs utilize platinum complexes in the 2+ oxidation state, 152,153,155,157,158,160,163–165 the field is trending toward the development of systems using platinum(IV) prodrugs. The two additional ligand binding sites available in platinum(IV) complexes provide covalent bond attachment points for fine tuning chemical and physical properties.…”

Section: Nanoparticle Delivery Of Platinum(iv) Prodrugsmentioning

confidence: 99%

Monofunctional and Higher-Valent Platinum Anticancer Agents

2013

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Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed to overcome issues of toxicity and resistance inherent to treatment by the approved platinum anticancer agents. One approach has been the use of so-called “non-traditional” platinum(II) and platinum(IV) compounds that violate the structure-activity relationships that governed platinum drug-development research for many years. Another is the use of specialized drug delivery strategies. Here we describe recent developments from our laboratory involving monofunctional platinum(II) complexes together with an historical account of the manner by which we came to investigate these compounds and their relationship to previously studied molecules. We also discuss work carried out using platinum(IV) prodrugs and the development of nanoconstructs designed to deliver them in vivo.

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Section: Nanoparticle Delivery Of Platinum(iv) Prodrugsmentioning

confidence: 99%

Monofunctional and Higher-Valent Platinum Anticancer Agents

2013

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“…[10][11][12] In particular, current advanced techniques in drug targeting use delicate surface modifications for the conjugation of antiangiogenic and anticancer drugs. 13,14 SPIONs have the advantage of easy transportation in vivo to the desired site by an external electrical magnetic field. Once the external magnetic field is removed, magnetization disappears and the SPIONs remain at the target site for a certain period.…”

Section: Introductionmentioning

confidence: 99%

Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups

Hong¹,

Lee²,

Lee³

et al. 2011

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely utilized for the diagnosis and therapy of specific diseases, as magnetic resonance imaging (MRI) contrast agents and drug-delivery carriers, due to their easy transportation to targeted areas by an external magnetic field. For such biomedical applications, SPIONs must have multifunctional characteristics, including optimized size and modified surface. However, the biofunctionality and biocompatibility of SPIONs with various surface functional groups of different sizes have yet to be elucidated clearly. Therefore, it is important to carefully monitor the cytotoxicity and genotoxicity of SPIONs that are surfaced-modified with various functional groups of different sizes. In this study, we evaluated SPIONs with diameters of approximately 10 nm and 100~150 nm, containing different surface functional groups. SPIONs were covered with −O − groups, so-called bare SPIONs. Following this, they were modified with three different functional groups – hydroxyl (−OH), carboxylic (−COOH), and amine (−NH 2 ) groups – by coating their surfaces with tetraethyl orthosilicate (TEOS), (3-aminopropyl)trimethoxysilane (APTMS), TEOS-APTMS, or citrate, which imparted different surface charges and sizes to the particles. The effects of SPIONs coated with these functional groups on mitochondrial activity, intracellular accumulation of reactive oxygen species, membrane integrity, and DNA stability in L-929 fibroblasts were determined by water-soluble tetrazolium, 2′,7′-dichlorodihydrofluorescein, lactate dehydrogenase, and comet assays, respectively. Our toxicological observations suggest that the functional groups and sizes of SPIONs are critical determinants of cellular responses, degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity. Nanoparticles with various surface modifications and of different sizes induced slight, but possibly meaningful, changes in cell cytotoxicity and genotoxicity, which would be significantly valuable in further studies of bioconjugation and cell interaction for drug delivery, cell culture, and cancer-targeting applications.

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“…DTG is useful for observing slight changes in weight, which are not readily noticed on the TGA thermograms. In DTG, the rate of per cent weight loss versus time (dw/dt) is obtained from the first derivative of the TGA curve [15]. As the dashed lines in Figure 4 show, BSA presents a very steep curve around 300 C, whereas CdS displays a relatively flat peak at the same position.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of protein-coated CdS nanocrystals via microwave-assisted hydrothermal method

Xing

Guo

Miao

et al. 2012

Journal of Experimental Nanoscience

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CdS nanocrystals coated with protein were synthesised in the aqueous solution of bovine serum albumin protein by a rapid microwave-assisted hydrothermal method. Transmission electron microscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis (TGA) and cell cytotoxicity were used to characterise the morphology, composition and properties of the nanocrystals. The results indicate that the as-prepared CdS nanocrystals were wrapped up with the protein. The cytotoxicity profile on the human cervical cancer cell line HeLa shows that the potential cellular toxicity of the nanocrystals is efficiently prevented due to the presence of protein coating, which may offer the possibility of applications in biomedical research.

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Superparamagnetic magnetite nanocrystal clusters as potential magnetic carriers for the delivery of platinum anticancer drugs

Cited by 67 publications

References 44 publications

Monofunctional and Higher-Valent Platinum Anticancer Agents

Monofunctional and Higher-Valent Platinum Anticancer Agents

Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups

Fabrication of protein-coated CdS nanocrystals via microwave-assisted hydrothermal method

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