2013
DOI: 10.1200/jco.2013.31.15_suppl.3083
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Superparamagnetic nanoparticles targeting cancer cells invading the extracellular matrix.

Abstract: 3083 Background: Metastatic cancer cells secrete matrix metalloproteinases (MMP), which allow cancer cells to burrow their way to the nearby vasculature. Therefore, MMPs are potential targets for anticancer treatment. Nanoparticles (NPs) can be crafted to adhere to the ECM and subsequently be released in response to advance of invasive cells. The objective of the study is to elucidate the interaction of cancer cells in a three-dimensional culture, with functionalized SPIONS targeted to the extracellular matri… Show more

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