Superselective adrenal arterial embolization for primary aldosteronism without lateralized aldosterone secretion: an efficacy and safety, proof-of-principle study

Qiu, Jian; Li, Ning; Xiong, Hongliang; Yang, Jing; Li, Yun-De; Hu, Chenkai; Lai, Ze-Qun; Liang, Ning-Peng; Zhang, Hongjin; Jiang, Xiongjing; Yan, Dong

doi:10.1038/s41440-023-01236-8

Cited by 12 publications

(4 citation statements)

References 33 publications

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“…A total of 7 studies with 222 patients were included in our meta-analysis ( Table 1 , Figure 1 ). All studies were prospective studies and only one of them was RCT ( 12 - 18 ). Five of included studies were single-arm studies with only one group of patients undergoing AAE.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, hypertension of 24.3% patients in Zhou’s study was cured by AAE ( 17 ). Qiu and colleagues explored the effect of AAE in patients suffering from bilateral PA ( 18 ). They found that hypertension disappeared in 12.9% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, the hypertension was improved in most patients. Moreover, 41.4% patients with complete biochemical success had a regression of left ventricle hypertrophy ( 18 ). By contrast, MRAs cannot inhibit the overproduction of aldosterone and thereby had no apparent benefit to cardiac remodeling ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

“…No intraoperative hypertensive crisis or severe arrhythmias was recorded during AAE procedure in these studies included in our meta-analysis. Nonetheless, it was recommended that intravenous antihypertensive medications, vasopressors, and antiarrhythmic medications should be routinely available when performing AAE ( 18 ). Moreover, our finding indicated that AAE had no apparent influence on the level of cortisol.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and safety of adrenal arterial embolization for primary aldosteronism: a systematic review and meta-analysis

Fu,

Xu,

Wang

et al. 2024

Gland Surg

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Background Primary aldosteronism (PA) is related with resistant hypertension and cardiovascular events. Adrenal artery embolization (AAE) is a choice for patients who refused surgery and medical therapy. However, whether AAE can effectively and safely treat PA is unclear. We performed this meta-analysis to determine the efficacy and safety of AAE for patients with PA. Methods Databases including Cochrane Library, Embase, PubMed and Web of Science were used to obtain relevant articles published before July 30, 2023. The primary outcome was blood pressure before and after AAE. The second outcomes included changes in plasma aldosterone level, serum potassium level, and plasma cortisol level. Results Finally, 7 prospective studies with 222 patients were included. The results showed that systolic and diastolic blood pressure was reduced by 21.68 mmHg (P<0.001) and 10.54 mmHg (P=0.007) respectively after AAE. The change in plasma aldosterone and serum potassium level was −11.52 ng/dL and 0.61 mmol/L respectively (P<0.001), whereas the reduction in cortisol level was not apparent. Moreover, AAE is a relatively safe procedure which only causes some minor complications such as back pain and fever. Conclusions This meta-analysis indicated that AAE could effectively and safely treat PA. It is a good choice for patients that are not suitable for adrenalectomy or drug therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%