Supplement Use in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Systematic Review

Greif, Dylan N.; Emerson, Christopher P.; Allegra, Paul R.; Arizpe, Azael; Mansour, Kailey L.; Cade, William H.; Baraga, Michael G.

doi:10.1016/j.arthro.2020.04.047

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…Twenty-two systematic reviews including 142 primary RCTs were included in this review (figure 1). 25–46 These systematic reviews were published between 2004 and 2021, included mostly male participants (56%–95% men) and focused almost exclusively on ACLR populations (table 1). No systematic reviews evaluating interventions following isolated meniscal injury in persons with a mean age of ≤30 years were identified.…”

Section: Resultsmentioning

confidence: 99%

“…Very low-certainty evidence from one review (10 RCTs) suggests that protein-based supplements taken between 6 and 18 months postoperatively may help to promote quadriceps size and strength following ACLR 38. Very low to low-certainty evidence of no effect was observed for creatine, vitamin and hormone-based supplements on quadriceps strength and self-reported function.…”

Section: Resultsmentioning

confidence: 99%

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Rehabilitation after anterior cruciate ligament and meniscal injuries: a best-evidence synthesis of systematic reviews for the OPTIKNEE consensus

et al. 2022

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ObjectiveSynthesise evidence for effectiveness of rehabilitation interventions following ACL and/or meniscal tear on symptomatic, functional, clinical, psychosocial, quality of life and reinjury outcomes.DesignOverview of systematic reviews with Grading of Recommendations Assessment, Development and Evaluation certainty of evidence.Data sourcesMEDLINE, EMBASE, CINAHL, SPORTDiscus and Cochrane Library.Eligibility criteriaSystematic reviews of randomised controlled trials investigating rehabilitation interventions following ACL and/or meniscal tears in young adults.ResultsWe included 22 systematic reviews (142 trials of mostly men) evaluating ACL-injured individuals and none evaluating isolated meniscal injuries. We synthesised data from 16 reviews evaluating 12 different interventions. Moderate-certainty evidence was observed for: (1) neuromuscular electrical stimulation to improve quadriceps strength; (2) open versus closed kinetic chain exercises to be similarly effective for quadriceps strength and self-reported function; (3) structured home-based versus structured in-person rehabilitation to be similarly effective for quadriceps and hamstring strength and self-reported function; and (4) postoperative knee bracing being ineffective for physical function and laxity. There was low-certainty evidence that: (1) preoperative exercise therapy improves self-reported and physical function postoperatively; (2) cryotherapy reduces pain and analgesic use; (3) psychological interventions improve anxiety/fear; and (4) whole body vibration improves quadriceps strength. There was very low-certainty evidence that: (1) protein-based supplements improve quadriceps size; (2) blood flow restriction training improves quadriceps size; (3) neuromuscular control exercises improve quadriceps and hamstring strength and self-reported function; and (4) continuous passive motion has no effect on range of motion.ConclusionThe general level of evidence for rehabilitation after ACL or meniscal tear was low. Moderate-certainty evidence indicates that several rehabilitation types can improve quadriceps strength, while brace use has no effect on knee function/laxity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Rehabilitation after anterior cruciate ligament and meniscal injuries: a best-evidence synthesis of systematic reviews for the OPTIKNEE consensus

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Very-low certainty evidence from one review (10 RCTs) suggests that protein-based supplements taken between 6 and 18 months postoperatively may help to promote quadriceps size and strength following ACLR. [36] There was also very-low certainty evidence for protein-based supplements taken for the first 3 months post-ACLR to improve graft maturation. Very-low to low certainty evidence of no effect was observed for creatine-, vitamin and hormone-based supplements on any outcome.…”

Section: Supplement Usementioning

confidence: 99%