Supplemental progesterone induces temporal changes in luteal development and endometrial transcription in beef cattle

Batista, E. O. S.; Cardoso, Beatriz de Oliveira; Oliveira, M. L.; Cuadros, F. D. C.; Mello, Bárbara Piffero; Sponchiado, Mariana; Monteiro, B.M.; Pugliesi, Guilherme; Binelli, Mário

doi:10.1016/j.domaniend.2019.02.001

Cited by 14 publications

(9 citation statements)

References 25 publications

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“…Other studies reported the adverse effects of exogenous P4 treatment, with an increase in early luteolysis (Batista et al, 2019; O'Hara et al, 2014; Pugliesi et al, 2014). Although the supplemented groups showed lower vascular perfusion, this result was not found in the present study; this difference can be attributed to the type of P4 used, dose, and especially the day of application.…”

Section: Discussionmentioning

confidence: 96%

“…Although the supplemented groups showed lower vascular perfusion, this result was not found in the present study; this difference can be attributed to the type of P4 used, dose, and especially the day of application. The dose and time of application of long-acting injectable P4 appear decisive in the results obtained after this supplementation, as studies that used higher concentrations of P4 or performed supplementation before day 5 after AI reported a compromise in the functionality of the CL (Batista et al, 2019;O'Hara et al, 2014;Pugliesi et al, 2014). Additionally, studies using lower doses of long-acting P4 or supplemented 5 days after AI did not report changes in early luteolysis (Couto et al, 2019;Pugliesi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Further, supplementation had no effects on the size and volume of the CL (Beltman et al, 2009; Monteiro et al, 2015; Nascimento et al, 2013). On the contrary, some studies have reported that P4 supplementation (mainly long‐acting) during dioestrous affects CL development and induces luteolysis (Batista et al, 2019; O'Hara et al, 2014; Pugliesi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Pugliesi et al (2014) observed a higher frequency of early luteolysis in animals supplemented with 300 mg of long-acting injectable P4 at 2 days after AI. O'Hara et al (2014) evaluated animals treated with a P4 device from days 3 to 5 or up to 7 days after ovulation Batista et al (2019). reported that a single injection with 300 mg of long-acting P4 on the third day after ovulation increased the proportion of cows showing early luteolysis, increased P4 concentration on days 4 and 5 in treated animals relative to control animals, and decreased CL blood flow, regardless of the treatment.…”

mentioning

confidence: 99%

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Effect of increased serum progesterone on luteal morphology and function, pregnancy, and gestational loss in Nelore cows

Couto

Guerson

Caparelli

et al. 2022

Reprod Domestic Animals

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The aim of the present study was to determine the impact of different strategies for increasing the level of serum progesterone (P4) on luteal morphology and function in bovine females. The effects of increasing P4 on pregnancy rate and gestational loss (GL) in Nelore cows subjected to timed artificial insemination (TAI) were also evaluated. A total of 939 cows were divided into three groups: P4LA (n = 305), 150 mg of long‐acting injectable P4 7 days after TAI; GnRH (n = 306), 10 μg of buserelin acetate 7 days after TAI; and control (n = 328), no hormone treatment after TAI. Doppler ultrasound assessments and P4 measurements were performed on days 7 and 16 after TAI. The pregnancy rate and GL as a function of treatment were compared using the SAS GLIMMIX procedure. Corpus luteum (CL) vascular perfusion, volume, and plasma P4 concentration were analysed using the SAS PROC MIXED procedure. No significant difference was found among the treatments in terms of volume, number of pixels, and CL intensity or in the serum P4 concentration at 7 days after ovulation. The CL blood flow at 16 days after ovulation was lower in the P4LA and GnRH groups than that in the control group (p < .01). Serum concentrations of P4 at 16 days after ovulation were higher in the P4LA and GnRH groups than those in the control group (p = .04). A difference in the pregnancy rate (p = .003) and a trend in GL (p = .07) as a function of treatment were found. Overall, long‐acting injectable P4 supplementation on day 7 after TAI or GnRH administration affected CL vascularization and increased the serum concentrations of P4 16 days after ovulation, promoting better pregnancy rates than the control.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of increased serum progesterone on luteal morphology and function, pregnancy, and gestational loss in Nelore cows

Couto

Guerson

Caparelli

et al. 2022

Reprod Domestic Animals

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“…To determine progesterone concentrations, blood samples were taken on days 3.5 (84 th h), 7, 12, and 18 days after AI (Carter et al 2008;Batista et al 2019). Blood samples from vena coccygea were collected into 10 ml vacuum ethylenediaminetetraacetic acid tubes.…”

Section: Blood Sample Collectionmentioning

confidence: 99%

Effect of progesterone, human chorionic gonadotropin and progesterone + human chorionic gonadotropin treatment on conception rates in repeat breeder cows

Alkan

Erdem

2020

Acta Vet. Brno

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The aim of this study was to investigate the effects of hormonal support on the pregnancy rate in repeat breeder cows. Prostaglandin F2α + Ovsynch oestrus synchronization protocol was applied to the cows. Following the fixed time insemination (day 0), the cows were divided into 4 groups. In Group 1 (n = 42), progesterone releasing intravaginal device (PRID) was placed vaginally at 84 h and removed on the 9th day after the artificial insemination. In Group 2 (n = 40), the cows were administered human chorionic gonadotropin (hCG) on the 7th day. Group 3 (n = 45) was applied a combination of progesterone and hCG. Group 4 (n = 42) was not given any treatment. Blood samples were collected from all cows 4 times on days 3.5, 7, 12, and 18 to evaluate progesterone concentrations. The pregnancy rates were 40.47%, 37.50%, 44.44%, and 30.95% in Group 1, 2, 3, and 4, respectively (P > 0.05). In addition, in cows with progesterone concentrations <2 ng/ml on day 3.5, the pregnancy rates were found to be lower than in the cows with progesterone concentrations >2 ng/ml in Group 4 (P < 0.05). Progesterone supplementation in cows with progesterone concentrations < 2 ng/ml appeared to increase pregnancy rates (P < 0.05) in Groups 1 and 3. As a result, post-insemination hormonal applications in the repeat breeder cows did not increase the pregnancy rate. However, it was concluded that determination of progesterone concentrations on day 3.5 following artificial insemination and then hormonal support in the cows with low concentrations would increased the pregnancy rate.

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Supplementation with long-acting injectable progesterone 3 days after TAI impaired luteal function in buffaloes

Cavalcante de Souza,

Gonella-Diaza,

de Carvalho

et al. 2024

Trop Anim Health Prod

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Supplemental progesterone induces temporal changes in luteal development and endometrial transcription in beef cattle

Cited by 14 publications

References 25 publications

Effect of increased serum progesterone on luteal morphology and function, pregnancy, and gestational loss in Nelore cows

Effect of increased serum progesterone on luteal morphology and function, pregnancy, and gestational loss in Nelore cows

Effect of progesterone, human chorionic gonadotropin and progesterone + human chorionic gonadotropin treatment on conception rates in repeat breeder cows

Supplementation with long-acting injectable progesterone 3 days after TAI impaired luteal function in buffaloes

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