Supplementary Figures 1 through 6 from Aspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFκB–IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells

Abstract

<p>Supplementary Figure S1: Immunohistological images representing ER, PR and Her2 staining of primary tumor cells and schematic representation showing flow cytometric sorting. Supplementary Figure S2: FAC-based chemotherapy increases CSC pool in different breast cancer cells. Supplementary Figure S3: FAC-based chemotherapy generates aggressive CSC pool. Supplementary Figure S4: Therapy fails to induce CSC-markers in purified NSCCs of MCF-7 cells. Supplementary Figure S5: Therapy induces translocation of NFκB in nucleus of CSCs. Supplementary Figure S6: Aspirin treatment perturbs NFκB nuclear translocation in CSC-enriched spheres and chemo-sensitizes CSCs to genotoxic therapy.</p>