Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise

Abstract

Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 h thereafter for 24 h, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 ± 11.5 and 3.9 ± 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 h later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05). In conclusion, a single dose of 140 mg Zynamite® combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance.

Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study

“…A number of recent studies have assessed the potential efficacy of a mango leaf extract standardized to a minimum of 60% mangiferin (Zynamite ® ). In terms of physical performance, several of these studies have assessed the ergogenic effects in humans of both acute [33][34][35][36] and longer-term supplementation [34] with this mango leaf extract combined with the polyphenols luteolin or quercetin. This research has demonstrated an improved performance during high intensity exercise [33][34][35], increased brain oxygenation [33,34], maximal aerobic capacity [33], increased muscle oxygen extraction [34,35] and the attenuation of muscle damage and improvements in the time course of decreased muscle performance [37].…”

Nutrition and Muscle Recovery

“…Nutritional supplements were studied in four studies (33.2%) in this Special Issue [1,2,4,12]. Bazzucchi et al [1] and Martin-Rincon et al [4] have studied the effect of polyphenols on muscle recovery, EIMD, and muscle pain, with quercetin (Q) in monotherapy and quercetin plus Zynamite ® (mango leaf extract), respectively. Q is a flavonoltype polyphenol and Zynamite ® is a natural polyphenol; both have antioxidant and anti-inflammatory attributes that may stop EIMD and promote muscle recovery [1,4].…”

“…Bazzucchi et al [1] and Martin-Rincon et al [4] have studied the effect of polyphenols on muscle recovery, EIMD, and muscle pain, with quercetin (Q) in monotherapy and quercetin plus Zynamite ® (mango leaf extract), respectively. Q is a flavonoltype polyphenol and Zynamite ® is a natural polyphenol; both have antioxidant and anti-inflammatory attributes that may stop EIMD and promote muscle recovery [1,4]. The supplementation with Q (1 gr/d) for 14 days following a double-blind crossover study design improve recovery from EIMD, the deterioration of neuromuscular function, and modulated the increase in muscular biomarkers such as creatine kinase (CK) and lactatedehydrogenase (LDH) [1] in healthy men.…”

“…The supplementation with Q (1 gr/d) for 14 days following a double-blind crossover study design improve recovery from EIMD, the deterioration of neuromuscular function, and modulated the increase in muscular biomarkers such as creatine kinase (CK) and lactatedehydrogenase (LDH) [1] in healthy men. Similarly, an only dose before 60 min the exercise (140 mg Zynamite ® plus 140 mg quercetin), followed by after 3 extra-doses every 8 h allowed modulates EIMD and stimulates the recovery of muscle performance [4]. Recovery of muscle strength and performance after intense exercise is enhanced by polyphenol supplementation, probably due to protection against oxidative damage that prevents postexercise muscle soreness.…”

“…Recovery of muscle strength and performance after intense exercise is enhanced by polyphenol supplementation, probably due to protection against oxidative damage that prevents postexercise muscle soreness. These effects impact the redox process and factors acting at the central nervous system level by eliminating free radicals involved in nociception [1,4].…”