The widespread use of Internet technology has changed people’s traditional life mode and created a new market transaction mode, namely, e-commerce platform. The Internet of Things can carry out real-time monitoring and management of any product in e-commerce and not only can realize information sharing in commercial activities but also can play a greater role in the protection of personal and enterprise information security. In this context, the efficiency and low cost of information flow, cash flow, logistics, and human resources among enterprises are particularly important. The Internet of Things technology is a means to effectively improve and optimize the operation mode of the supply chain. This paper analyzes the status of traditional supply chain management, which discusses the development of a supply chain management based on the Internet of Things technology. Finally, this paper analyzes how to realize the optimization strategy of e-commerce supply chain management based on the Internet of Things technology, which provides strong support for the informatization of e-commerce supply chain management. Through the application of the Internet of Things technology, small- and medium-sized enterprises can optimize the workflow and circulation links of the e-commerce supply chain management, enhance the matching level of product value and information transmission, improve the supply chain operation mechanism, and increase economic benefits.