PurposeThis paper aims to investigate the relationship between information technology (IT) capabilities, information integration and supply chain resilience within the context of a developing country.Design/methodology/approachEmploying a structured questionnaire survey, the study collected cross-sectional data from 205 agro-food processing firms in Uganda, drawn from a sample of 248. The data were subsequently analyzed using SPSS version 27 to validate the hypothesized relationships.FindingsThe study findings revealed that IT capabilities and information integration are positively and significantly associated with supply chain resilience. Moreover, it established a positive and significant link between IT capabilities and information integration. The results further revealed both IT capabilities and information integration account for 62.2% of the variance in supply chain resilience (SCRES) in agro-food processing firms in Uganda. Notably, the findings revealed the partial mediating role of information integration, addressing the need to understanding the mechanisms through which IT capabilities influence SCRES.Research limitations/implicationsFirst, the study used a cross-sectional design which makes it difficult to test causality. Some of the study variables need to be studied over time due to their inherent behavioral elements such as collaboration and information sharing. Hence, future research that could, where possible, collect longitudinal data on the study variables would add value to the findings. Second, the study was limited to agro-food processing firms in Uganda in selected districts of Kampala, Wakiso, Mukono and Jinja. Further research needs to be done in other sectors such as service industry and other geographical locations in Uganda and other developing economies to provide more generality of the findings. Third, the study was based on IT capabilities, information integration and supply chain resilience. There are other variables that affect supply chain resilience such as business continuity planning strategy, interactions between teams within an organization in building resilience, supply chain velocity, system orientation and flexibility among others which can be interesting for further research.Practical implicationsManagers are advised to motivate their IT-related personnel. Efficient use of IT systems by staff, especially who are skillful at self-study, enhances their ability to respond to disruptions accordingly. This enhances SCRES. Additionally, to get feedback from supply chain stakeholders, agro-food processing firms should assess the quality of their supply chain services through using IT capabilities as well as integrating their information.Originality/valueThis study contributes to existing literature by adopting information processing perspective to provide an empirical understanding of IT capabilities and information integration as key resources and capabilities essential for information processing in building SCRES. Furthermore, the study introduces the novel insight of the mediating role of information integration as a pathway in which IT capabilities enhance SCRES in agro-food processing firms in Uganda.