With increasing aging population, dementia is a major healthy concern in US and worldwide. Increasing evidence also suggests that coexistence of diabetes and depression exacerbate the high prevalence of dementia in elderly. Recent advanced medical care, diagnostic features, timely provided medicines and caregiving facilities, lifespan is increased in elderly individuals with diabetes and depression. Our mini-review discusses the latest developments in depression, diabetes, and dementia research. We also covered interlinks between depression, diabetes, and dementia in relation to gender, age, and lifestyle risk factors. We also briefly discussed, pharmacological and lifestyle intervention to reduce diabetes, depression, and dementia.