Supportive therapy during COVID-19: The proposed mechanism of short-chain fatty acids to prevent cytokine storm and multi-organ failure

Jardou, Manon; Lawson, Roland

doi:10.1016/j.mehy.2021.110661

Cited by 20 publications

(15 citation statements)

References 37 publications

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“…The concentration and proportion of SCFAs in the intestinal lumen and bloodstream vary according to diet, GM, and physiological status [ 230 ]. As a consequence of COVID-19-derived dysbiosis, SCFAs have been proposed as a support treatment to prevent the cytokine storm and multiorgan failure in COVID-19, especially butyric acid due to its immunoregulatory activities [ 231 ].…”

Section: Gut Microbiota Metabolites In the Covid-19 Infection And Pos...mentioning

confidence: 99%

Role of Micronutrients and Gut Microbiota-Derived Metabolites in COVID-19 Recovery

Hernández-Flores

Pedraza-Brindis

Cárdenas-Bedoya

et al. 2022

IJMS

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A balanced and varied diet provides diverse beneficial effects on health, such as adequate micronutrient availability and a gut microbiome in homeostasis. Besides their participation in biochemical processes as cofactors and coenzymes, vitamins and minerals have an immunoregulatory function; meanwhile, gut microbiota and its metabolites coordinate directly and indirectly the cell response through the interaction with the host receptors. Malnourishment is a crucial risk factor for several pathologies, and its involvement during the Coronavirus Disease 2019 pandemic has been reported. This pandemic has caused a significant decline in the worldwide population, especially those with chronic diseases, reduced physical activity, and elder age. Diet and gut microbiota composition are probable causes for this susceptibility, and its supplementation can play a role in reestablishing microbial homeostasis and improving immunity response against Coronavirus Disease 2019 infection and recovery. This study reviews the role of micronutrients and microbiomes in the risk of infection, the severity of disease, and the Coronavirus Disease 2019 sequelae.

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Section: Gut Microbiota Metabolites In the Covid-19 Infection And Pos...mentioning

confidence: 99%

Role of Micronutrients and Gut Microbiota-Derived Metabolites in COVID-19 Recovery

Hernández-Flores

Pedraza-Brindis

Cárdenas-Bedoya

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Because of this, they are involved in the regulation of many cellular functions such as migration [ 211 , 220 , 221 ] and survival [ 211 , 222 , 223 ]. Butyrate, which is the strongest HDAC inhibitor [ 224 , 225 ], can cause macrophages to metabolically switch toward an anti-inflammatory M2 phenotype by inhibiting HDAC3 [ 226 , 227 ]. Another HDAC-related effect of butyrate is the inhibition of nitric oxide production (via iNOS) and lipopolysaccharide-induced proinflammatory cytokines (IL-6, IL-12) [ 227 , 228 ].…”

Section: Short-chain Fatty Acidsmentioning

confidence: 99%

“…Butyrate, which is the strongest HDAC inhibitor [ 224 , 225 ], can cause macrophages to metabolically switch toward an anti-inflammatory M2 phenotype by inhibiting HDAC3 [ 226 , 227 ]. Another HDAC-related effect of butyrate is the inhibition of nitric oxide production (via iNOS) and lipopolysaccharide-induced proinflammatory cytokines (IL-6, IL-12) [ 227 , 228 ]. In addition, the anti-inflammatory effect of butyrate is associated with inhibition of the NF-kB signaling pathway as well as production by mononuclear cells and neutrophils of anti-inflammatory cytokines such as IL-10 [ 225 , 227 ].…”

Section: Short-chain Fatty Acidsmentioning

confidence: 99%

Anti-Inflammatory Function of Fatty Acids and Involvement of Their Metabolites in the Resolution of Inflammation in Chronic Obstructive Pulmonary Disease

Kotlyarov

Kotlyarova

2021

IJMS

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Lipid metabolism plays an important role in many lung functions. Disorders of lipid metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD). Lipids are involved in numerous cross-linkages with inflammation. Recent studies strongly support the involvement of fatty acids as participants in inflammation. They are involved in the initiation and resolution of inflammation, including acting as a substrate for the formation of lipid mediators of inflammation resolution. Specialized pro-inflammatory mediators (SPMs) belonging to the classes of lipoxins, resolvins, maresins, and protectins, which are formed enzymatically from unsaturated fatty acids, are now described. Disorders of their production and function are part of the pathogenesis of COPD. SPMs are currently the subject of active research in order to find new drugs. Short-chain fatty acids are another important participant in metabolic and immune processes, and their role in the pathogenesis of COPD is of great clinical interest.

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“…Clinical characteristics of COVID-19 shown as fever, dry cough, dyspnea, septic shock, coagulation dysfunction and multiple organ dysfunction or failure (Wang et al, 2020). Jardou and Lawson (2021) was pointed that butyrate supplementation for preventing the cytokine storm facilitate excessive activation of immune system and further development of disease. Butyrate contributes to resistance against viral in the lung that increased resistance against respiratory viral infection with lower respiratory tract infection (LRTI) (Haak et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Butyrate limits the replication of porcine epidemic diarrhea virus in intestine epithelial cells by enhancing GPR43-mediated IFN-III production

Fan²,

Shen³

et al. 2023

Front. Microbiol.

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Porcine epidemic diarrhea virus (PEDV) is a threat to the health of newborn piglets and has a significant impact on the swine industry. Short-chain fatty acids (SCFAs) are gut microbial metabolites that regulate intestinal function through different mechanisms to enhance the intestinal barrier and immune function. In this study, we aimed to determine whether butyrate displayed a better effect than other SCFAs on limiting PEDV replication in porcine intestinal epithelial cells. Mechanistically, butyrate treatment activated the interferon (IFN) response and interferon-stimulated gene (ISG) expression. Further experiments showed that inhibition of GPR43 (free fatty acid receptor 2) in intestinal epithelial cells increased virus infection and reduced antiviral effects through IFN λ response. Our findings revealed that butyrate exerts its antiviral effects by inducing GPR43-mediated IFN production in intestinal epithelial cells.

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Supportive therapy during COVID-19: The proposed mechanism of short-chain fatty acids to prevent cytokine storm and multi-organ failure

Cited by 20 publications

References 37 publications

Role of Micronutrients and Gut Microbiota-Derived Metabolites in COVID-19 Recovery

Role of Micronutrients and Gut Microbiota-Derived Metabolites in COVID-19 Recovery

Anti-Inflammatory Function of Fatty Acids and Involvement of Their Metabolites in the Resolution of Inflammation in Chronic Obstructive Pulmonary Disease

Butyrate limits the replication of porcine epidemic diarrhea virus in intestine epithelial cells by enhancing GPR43-mediated IFN-III production

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