Suppression of natural killer cell activity by splenocyte transplantation in a rat model of endometriosis

Ota, Hirotaka; Rong, Huang; Igarashi, Shigeru; Tanaka, Toshinobu

doi:10.1093/humrep/17.6.1453

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…Salto et al found delayed ovulation and a higher incidence of pseudopregnancy in asplenic rats. These disorders were normalized after the injection of splenocytes, indicating an association of splenic tissue with ovarian functions 17 . Okely et al studied the dynamics of ovulation associated with mediators of acute inflammation and observed fewer leukocytes in the ovaries of splenectomized rats, indicating that the spleen releases leukocytes for the defense of the ovary in the ovulatory period 18 .…”

Section: Discussionmentioning

confidence: 92%

Splenectomy is associated with sexual dysfunctions and decreased libido

Sabino

Petroianu

2021

Sci Rep

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The removal of the spleen due to disease or trauma may be followed by disorders due to the asplenism, including immunodeficiency, hematological and metabolic diseases, mainly dyslipidemia, which can lead to sepsis, pulmonary embolism and early death. Although patients frequently report sexual disinterest after splenectomy, this feature has been experimentally studied only in a translational investigation performed by the same group of this work. To study libido and other sexual functions after the complete removal of the spleen in humans. This study was performed on 60 healthy adults, 30 men and 30 women, after more than 1 year of total splenectomy to treat isolated splenic trauma. The International Index of Erectile Function was applied to men and the Female Sexual Function Index to women. The analysis compared the responses obtained in the periods before and after the splenectomy. Laboratory tests with hematological and biochemical analyses, including sex hormones, were performed in all patients. The pre- and postoperative results were compared in each group using the paired t-test, with each patient being his or her own control and with significance to p < 0.05. A decrease in libido and an increase in sexual dysfunction was observed after splenectomy in all men and women, p < 0.001. All postoperative laboratory tests showed normal values in both genders. Asplenia is associated with a marked decrease in libido and intense sexual dysfunction in both men and women, with normal hematological and biochemical laboratory tests, including hormonal exams.

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Section: Discussionmentioning

confidence: 92%

Splenectomy is associated with sexual dysfunctions and decreased libido

Sabino

Petroianu

2021

Sci Rep

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“…Salto et al (1988) found delayed ovulation and a higher incidence of pseudopregnancy in asplenic rats. These disorders were normalized after the injection of splenocytes, indicating an association of splenic tissue with ovarian functions [17]. Okely et al (2010) studied the dynamics of ovulation associated with mediators of acute in ammation and observed fewer leukocytes in the ovaries of splenectomized rats, indicating that the spleen releases leukocytes for the defense of the ovary in the ovulatory period [18].…”

Section: Discussionmentioning

confidence: 99%

Splenectomy Is Associated with Sexual Dysfunctions and Decreased Libido

Sabino

Petroianu

2021

SSRN Journal

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BACKGROUND: The removal of the spleen due to disease or trauma may be followed by disorders due to the asplenism, including immunode ciency, hematological and metabolic diseases, mainly dyslipidemia, which can lead to sepsis, pulmonary embolism and early death. Although patients frequently report sexual disinterest after splenectomy, this feature has been experimentally studied only in a translational investigation performed by the same group of this work.OBJECTIVE: To study libido and other sexual functions after the complete removal of the spleen in humans.METHODS: This study was performed on 60 healthy adults, 30 men and 30 women, after more than one year of total splenectomy to treat isolated splenic trauma. The International Index of Erectile Function was applied to men and the Female Sexual Function Index to women. The analysis compared the responses obtained in the periods before and after the splenectomy. Laboratory tests with hematological and biochemical analyses, including sex hormones, were performed in all patients. The pre-and postoperative results were compared in each group using the paired t-test, with each patient being his or her own control and with signi cance to p < 0.05. RESULTS: A decrease in libido and an increase in sexual dysfunction was observed after splenectomy in all men and women, p < 0.001. All postoperative laboratory tests showed normal values in both genders. CONCLUSION: Asplenia is associated with a marked decrease in libido and intense sexual dysfunction in both men and women, with no change in hematological and biochemical laboratory tests, including hormonal exams.

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“…Investigators have noticed directly reduced immune responses to autologous endometrial tissue, including decreased T cell-mediated cytotoxicity, decreased T cell-dependent B-cell proliferation, and decreased lymphocytic infiltration in response to intradermal injection of autologous endometrial antigens. Further, there appear to be significant reductions in natural-killer cell populations as well as decreased natural-killer cell activity in women with endometriosis (5)(6)(7)(8)(9)(10)(11). Taking the immunologic alterations into account that are present in women with endometriosis, Braum et al (12) suggested that macrophage activators, such as interferons, could be useful in addition to hormone suppression therapy to control and eliminate the growth of endometrial ectopic tissue.…”

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confidence: 99%