Suppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions

Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers

“…Previous reports indicated that LAB (i.e. Lactobacillus plantarum 10hk2 and L. johnsonii HY7042) suppressed proinflammatory cytokine production via inhibiting NF-κB activation (Chon et al, 2010;Joo et al, 2011), which is consistent with the present result that LB down-regulated NF-κB expression. We also found that TP decreased intestinal NF-κB mRNA abundance on Days 56 and 84, which might mediate cytokines expression.…”

In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses

“…The activation of NF-κB is implicated in MAPK signaling pathway. Inhibition of MAPK family pathway, such as ERK, p38, and JNK, alleviates the production of proinflammatory cytokines [21]. The results showed that pinocembrin obviously down-regulated LPS-induced phosphorylation of ERK1/2, JNK and p38 pathways in a dose-dependent manner.…”

Metabolites of Lactobacillus plantarum 2142 Prevent Oxidative Stress-Induced Overexpression of Proinflammatory Cytokines in IPEC-J2 Cell Line

“…Two isolated proteins (p40 and p75) secreted by LGG were found effective in preventing mouse and human IEC lines from cytokineinduced apoptosis by regulating signaling cascade through Akt activation [35]. L. plantarum 10hk2-specific extracellular protein metabolites showed immunmodulatory effect to induce anti-inflammatory responses such as downregulation of TNF-α release in RAW 264.7 cells cultured with LPS [36]. Several antibacterial molecules other than bacteriocins, organic acids and hydrogen-peroxide have been found to be derived from lactobacilli, but the structural characterization has not been performed yet.…”