Suppression of TNF-α and free radicals reduces systematic inflammatory and metabolic disorders: Radioprotective effects of ginseng oligopeptides on intestinal barrier function and antioxidant defense

He, Lixia; Wang, Junbo; Sun, Bin; Zhao, Jian; Lin, Li; Teng, Xu; Li, Hui; Jing-Qin, Sun; Ren, Jinwei; Liu, Rui; Chen, Qihe; Zhang, Zhaofeng; Li, Yong

doi:10.1016/j.jnutbio.2016.09.019

Cited by 40 publications

(42 citation statements)

References 28 publications

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“…Previous studies have shown that apoptosis is closely related to the occurrence of gastric mucosal damage, and excessive apoptosis will destroy the integrity of the mucosa and eventually induce gastric ulcer [8,54]. The cellular apoptosis caused by ethanol could be primarily attributed to the upregulation of pro-apoptosis protein Bax and caspase-3, and down-regulation of the anti-apoptosis protein Bcl-2, thereby resulting in gastric mucosa dysfunction [11,30]. Additionally, NF-κB is the predominant mediator of redox imbalance and excessive generation of inflammatory cytokines [8,48].…”

Section: Discussionmentioning

confidence: 99%

The Gastroprotective Effect of Small Molecule Oligopeptides Isolated from Walnut (Juglans regia L.) against Ethanol-Induced Gastric Mucosal Injury in Rats

et al. 2020

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The study investigated the protective effect of walnut oligopeptides (WOPs) against ethanol-induced gastric injury using Sprague-Dawley (SD) rats. Rats were randomly divided into seven groups based on body weight (10/group), normal group, ethanol group, whey protein group (220 mg/kg body weight), omeprazole group (20 mg/kg body weight), and three WOPs groups (220, 440, 880 mg/kg body weight). After 30 days of treatment with WOPs, rats were given 5 mL/kg absolute ethanol by gavage to induce gastric mucosal injury. Gastric ulcer index (GUI) were determined and the following measured; gastric content pH, gastric mucin, endogenous pepsinogens (PG), prostaglandin E2 (PGE2), inflammatory cytokines, oxidative stress indicators, and the expression of apoptosis-related proteins were measured to evaluate the gastroprotective effect of WOPs. The results showed that the administration with WOPs markedly mitigated the hemorrhagic gastric lesions caused by ethanol in rats, and decreased the GUI, the gastric content pH, PG1, PG2, and NO levels, enhanced mucin and PGE2. Also, WOPs repressed gastric inflammation through the reduction of TNF-α, IL-6, IL-1β and increase IL-10 levels, and revealed antioxidant properties with the enhancement of superoxide dismutase, glutathione, and catalase activity, while reduction of malondialdehyde. Moreover, WOPs treatment significantly down-regulated Bax, caspase-3 and nuclear factor-κB p65 (NF-κB p65) expression, while up-regulating the expression of Bcl-2 and inhibitor kappa Bα (IκBα) protein. These results indicated that WOPs have protective effects against ethanol-induced gastric mucosal injury in rats through anti-inflammatory, anti-oxidation, and anti-apoptosis mechanisms.

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Section: Discussionmentioning

confidence: 99%

The Gastroprotective Effect of Small Molecule Oligopeptides Isolated from Walnut (Juglans regia L.) against Ethanol-Induced Gastric Mucosal Injury in Rats

et al. 2020

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“…Radioprotective agents capable of improving myelosuppression with high efficacy and low toxicity are particularly important for radiation oncology. Studies have shown acidic polysaccharide, oligopeptides, and other active components from Panax ginseng have radioprotective activity in mice (He et al, ; Kim et al, ). North American ginseng extract (total ginsenoside content: 11.7%) protected human lymphocytes against irradiation‐induced DNA damage (Lee et al, ; Lee, Johnke, Allison, O'Brien, & Dobbs, ; Lee, Wang, et al, ).…”

Section: Discussionmentioning

confidence: 99%

Radioprotective effects of dammarane sapogenins against ⁶⁰Co‐induced myelosuppression in mice

Dong

Yang

et al. 2018

Phytotherapy Research

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Radiotherapy frequently induces failure of hematopoietic system and leads to myelosuppression. The objective of this study was to investigate the protective effect of dammarane sapogenins (DS), the hydrolysed product of the constituent ginsenosides of Panax ginseng, which are produced by gut metabolism, on radiation-induced hematopoietic injury. Mice were exposed to 3.5 Gy Co γ-rays of total body radiation at a dose rate of 1.60 Gy per minute and treated with DS or granulocyte colony-stimulating factor immediately after radiation. The general condition of the mice, the peripheral blood cell counts, multiple colony forming unit (CFU) assays of hematopoietic progenitor cells, hematopoietic stem cell counts, bone marrow histology, and spleen colony forming unit counts were then investigated. Our results indicated that administration with DS could ameliorate Co-irradiation induced damage and significantly increase the number of peripheral blood cells (white blood cells and platelets), 5 types of hematopoietic progenitor cells CFU (CFU-GM, CFU-E, BFU-E, CFU-Meg, and CFU-GEMM), hematopoietic stem cell (Lin c-kit Scal-1 ) numbers, and CFUs in the spleen, as well as improved bone marrow histopathology. All together, these results confirmed the enhancement of DS on hematopoiesis.

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“…GOP were accordingly administered to the mice of these three GOP intervention groups at 0.125, 0.500, and 2.00 g/kg BW, respectively, whereas the control were received 10 mL/kg distilled water). The doses setting were refer to the previous study in our lab [ 19 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…Ginsenoside and polysaccharides are currently the most studied. Meanwhile, ginseng oligopeptides (GOPs) are a kind of nutrients with low molecular weight, high bioavailability, and absorption features, which have numerous potential physiological functions [ 19 , 20 ]. However, studies on the beneficial effects of ginseng oligopeptides (GOPs) on glycemia are rarely conducted.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Small Molecule Oligopeptides Isolated from Panax ginseng Meyer on Pancreatic Beta-Cell Dysfunction and Death in Diabetic Rats

Sun

et al. 2017

Nutrients

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To determine whether treatment with ginseng oligopeptides (GOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in rats induced by high-fat diet and low doses of alloxan, type 2 diabetes was induced in male Sprague–Dawley (SD) rats by injecting them once with 105 mg/kg alloxan and feeding them high-carbohydrate/high-fat diet with or without GOP administration (0.125, 0.5, and 2.0 g/kg Body Weight) for 7, 24, and 52 weeks. Oral glucose test tolerance (OGTT), plasma glucose, serum insulin, level of antioxidant, and beta cell function were measured. Morphological observation and immunohistochemistry study of insulin of islets was performed by light microscopy. The insulin level and the expression of NF-κB and Bcl-2 family in pancreatic islets were also detected by Western blot analysis. In addition, survival time and survival rate were observed. After the treatment, the abnormal OGTT were partially reversed by GOPs treatment in diabetic rats. The efficacy of GOPs was manifested in the amelioration of pancreatic damage, as determined by microscopy analysis. Moreover, GOPs treatment increased the normal insulin content and decreased the expression of the NF-κB-signaling pathway. Compared with those in the control model, the survival time and rate were significantly longer. It is suggested that GOPs exhibit auxiliary therapeutic potential for diabetes.

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Suppression of TNF-α and free radicals reduces systematic inflammatory and metabolic disorders: Radioprotective effects of ginseng oligopeptides on intestinal barrier function and antioxidant defense

Cited by 40 publications

References 28 publications

The Gastroprotective Effect of Small Molecule Oligopeptides Isolated from Walnut (Juglans regia L.) against Ethanol-Induced Gastric Mucosal Injury in Rats

The Gastroprotective Effect of Small Molecule Oligopeptides Isolated from Walnut (Juglans regia L.) against Ethanol-Induced Gastric Mucosal Injury in Rats

Radioprotective effects of dammarane sapogenins against ⁶⁰Co‐induced myelosuppression in mice

Beneficial Effects of Small Molecule Oligopeptides Isolated from Panax ginseng Meyer on Pancreatic Beta-Cell Dysfunction and Death in Diabetic Rats

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Suppression of TNF-α and free radicals reduces systematic inflammatory and metabolic disorders: Radioprotective effects of ginseng oligopeptides on intestinal barrier function and antioxidant defense

Cited by 40 publications

References 28 publications

The Gastroprotective Effect of Small Molecule Oligopeptides Isolated from Walnut (Juglans regia L.) against Ethanol-Induced Gastric Mucosal Injury in Rats

The Gastroprotective Effect of Small Molecule Oligopeptides Isolated from Walnut (Juglans regia L.) against Ethanol-Induced Gastric Mucosal Injury in Rats

Radioprotective effects of dammarane sapogenins against 60Co‐induced myelosuppression in mice

Beneficial Effects of Small Molecule Oligopeptides Isolated from Panax ginseng Meyer on Pancreatic Beta-Cell Dysfunction and Death in Diabetic Rats

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Radioprotective effects of dammarane sapogenins against ⁶⁰Co‐induced myelosuppression in mice